Smithkline Beecham Corporation

Glaxo Wellcome Inc.

Michael Simon Loft

Malcolm Stuart Nobbs

Brian Cox

Gita Punjabhai Shah

Dean David Edney

Rebecca Jane Moore

David Colclough

David Box

Iain Gillies

A compound of formula (I): namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with phosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relatively non-hygroscopic selective inhibitor of inducible nitric oxide synthase.

Nitric oxide synthase inhibitor phosphate salt

Pyrazine compounds

A compound of formula (I) wherein R,is selected from the group consisting of phenyl substituted by one or more halogen atoms, naphthyl and naphthyl substituted by one or more halogen atoms; R,is selected from the group consisting of &mdash;NH,and &mdash;NHC(&boxH;O)R,; R,is selected from the group consisting of &mdash;NR,R,, &mdash;NHC(&boxH;O)R,and hydrogen, R,is selected from the group consisting of hydrogen, -C,alkyl, -C,alkyl substituted by one or more halogen atoms, &mdash;CN, &mdash;CH,OH, &mdash;CH,OR,and &mdash;CH,S(O),R,; wherein R,represents C,alkyl or C,cycloalkyl, and R,and R,, which may be the same or different, are selected from hydrogen and C,alkyl, or together with the nitrogen atom to which they are attached, form a,-membered nitrogen containing heterocycle, which heterocycle can be further susbtituted with one or more C,alkyl; R,is selected from C,alkyl or C,alkyl substituted by one or more halogen atoms; x is an integer zero, one or two; and pharmaceutically acceptable derivatives thereof; with the proviso that R,does not represent (a); when R,is &mdash;NH,, and both R,and R,are hydrogen.

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Dartford, United Kingdom

Michael Simon Loft