Acurx Pharmaceuticals, LLC

Other

Boston University

Michael Silverman

Casey Cameron McComas

Xiang Y Yu

Minghua Wang

Li Huang Xing

Richard Soll

James L Cornette

Charles DeLisi

Benjamin L King

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections. 

DNA polymerase IIIC inhibitors and use thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacteria infections. 

A method, performed on a computer (10), for generating representations of a molecule, both two- and three-dimensional, is provided. The method includes establishing X, Y, and Z coordinate axes for the molecule to be modeled such that a rectangular region is established with sides parallel to the coordinate axes. The method also includes establishing a grid of coordinates on the X, Y, and Z coordinates axes with a grid mesh size of sufficient resolution to identify atom points of the molecule and solvent points. Next, the method includes identifying surface points which form a trace in one dimension in each Z cross-section, and generating tracing instructions for each Z cross-section by tracing along the surface points in the trace in each Z cross-section and writing the X, Y coordinates to instructions for controlling a computer display or for controlling a computer controlled milling machine. The method also includes generating on a computer display a two-dimensional grid and surface geometry for the molecule including atom identifications using the tracing steps for each Z cross-section. Additionally, the method includes cutting sheets representative of each Z cross-section with the milling instructions and assembling the sheets into three-dimensional models representative of the molecule.

Molecular modeling method and system

A system for two way communication under shallow water or between a swimmer and observer comprising a transceiver, a wire for conducting electrical signals connected to the transceiver, a watertight transducer housing that curvedly conforms to human heads incorporating a speaker/microphone transducer in watertight connection with the wire, an adjustable strap connected to the transducer housing so that it may be attached to a portion of a human body, and a hollow acoustic transmission tube in watertight connection with the transducer housing for sound transmission to an earplug which is inserted into a human ear.

Two way communication system for water sports

Submersible personal stereo using a source, such as a radio, of stereo signals, a pair of sealed chambers housing a pair of electro-acoustic transducer and acoustic transmissive tubing for transmitting sound from the chambers to ear plugs, the tubing being non-wet by water and of a small inner diameter to keep water from entering.

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Marblehead, MA, United States of America

Michael Silverman