Other

Curelab Oncology, Inc.

Scientific Industries, Inc.

Phylogency, Inc.

Michael Sherman

Yury Sherman

Ilya Alexandrov

Alexander Shneider

Franco Venanzi

Katerina Sherman

Victor Shifrin

Vladimir Gabai

Ian K Glasgow

Ramkumar Krishnan

Antonio Concetti

Maria Giovanna Sabbieti

Yehuda Buff

Ramkumur Krishnan

Abram Botvinnik

Vladimir Z Volloch

Dimitrios Agas

Anatoli Meriin

Vladimir Volloch

Provided herein are novel p62 compositions for the modulation of expression of a proinflammatory cytokines, osteogenic transcription factors, a bone resorptive factors and endogenous p62. Consequently, such p62 compositions are useful for prophylaxis and treatment of inflammatory diseases and related methods. In certain embodiments the inflammatory diseases are not cancer-related. In various embodiments, the inflammatory diseases include, but are not limited to osteoporosis, obesity, metabolic syndrome, type 2 diabetes, fat liver, inflammatory bowel disease, chronic pancreatitis, asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), osteoarthritis, multiple sclerosis (MS), psoriasis, congestive heart failure (CHF), atherosclerosis, neurodegenerative diseases (ALS, Parkinson, Alzheimer's, Huntington disease), depression, schizophrenia, gout, asbestosis and silicosis.

Methods and compositions relating to p62/SQSTM1 for the treatment and prevention of inflammation-associated diseases

Provided herein are novel p62 compositions for the prophylaxis and treatment of cancer and related methods. The invention also provides modified p62 compositions that increase the anti-cancer activity of p62.

Methods and compositions relating to P62 for the treatment and prophylaxis of cancer

The present invention relates to an apparatus for substantially horizontally oscillating one or more multi-well plates containing a liquid, a solid, or a mixture thereof that operates to thoroughly disrupt solid substances in multi-well plates. The apparatus provides oscillation of plates in a horizontal direction through the use of springs and rotating mechanical components. The apparatus includes a circular rotating ring having a toothed circumference that rotates horizontally, plate holder, and a spring attached to the housing and in constant contact with the plate holder. The apparatus can be used in a cold room or placed in a refrigerator to keep the substances at low temperature and to eliminate noise when the disruptor operates.

Apparatus for disruption of cell and tissue samples in multi-well plates

An apparatus for substantially horizontally oscillating one or more vessels containing a liquid, a solid, or a mixture thereof that operates to thoroughly disrupt and mix solid and liquid substances in vessels, like test tubes. The apparatus provides superior mixing through oscillation of the vessels both horizontal and vertical directions through the use of one or more springs and rotating mechanical components. The apparatus includes a circular rotating ring having a toothed circumference that rotates horizontally, at least one vessel support having a compartment configured to hold the one or more vessel vessels and a spring attached to the housing and in constant contact with each of the one or more vessel supports.

Apparatus for mixing and disruption of cell and tissue samples in vessels

A hand operated device for storing, measuring, and dispensing powder or granular materials, with a simplified structure and reduced number of parts. The housing integrates a material storage container with a dispenser, comprising: special compartments and sound damper, made of elastic porous material that makes use of the device quiet; a one touch assembly and disassembly of an inner space of the device where the dispenser is located; structural elements for dispensing a predetermined volume of the material or its fraction, including a way to reduce the length of the working stroke of the dispensing mechanism; wall extensions to prevent bridges of sticky particles forming; separating walls to allow delivery a more than one material stored in one device including more than one material transporting mechanisms inside the dispenser; and structural elements providing exact measuring, and sifting or pouting of the materials.

Device and industrial package for storing, measuring and dispensing powder and granular substances

A method of mixing together liquids or liquid/solid combinations, and mixing apparatus/universal combine utilizing a vertical spinning container or vessel having a rib, or a cross rib in its bottom wall. The container is spun about a vertical axis with no wobbling component to the motion. Meshed elements are used for high shear mixing. Start/stop routines, and variable acceleration/speed values are used, to facilitate complete mixing. Use of 'impeller' blade stirrers is completely eliminated.

Method and an apparatus/universal combine for agitation of liquids

A centrifuge having two arcuate slots to receive resilient, bendable mounting flanges that each carry a plurality of test tubes in side by side relation. The resilience of the mounting flanges enables them to flex and assume either the curvature of the slot, or a linear configuration enabling the flanges to be suspended in a flat condition, such as on a test rack. The arrays of test tubes is attached to the flanges via living hinges that enable the flexing to occur. The advantages are that simplified identification of individual test tubes, as well as reduced likelihood of intermixing of spillage are realized.

Holder for supporting test tubes side by side on a rack, and having a resilient mounting flange connecting the tubes to allow the holder to bend and fit into an angular slot of a centrifuge rotor

A device for automation of biological and medical tests wherein test subjects or specimens that are placed in test vessels are subsequently treated by different liquid reagents, including: at least two test vessels of dimensions providing accommodation of specimens, a hydraulic gravity feeding system to deliver the liquid reagents into the two test vessels, a hydraulic gravity discharging system to remove waste liquid or spent reagents from the test vessels and directing them into an apparatus for accommodation of the such waste liquid or spent reagents, and a control system operating the device. A mechanical system is provided for agitating the test vessels.

Device for protein detecting tests

A device for mixing, homogenization, resuspension, disintegration, disruption, or centrifugation of media placed in test tubes, including: a rotor having a replaceable closure; a driver having a substantially vertical shaft; a sleeve having a spiral groove and a bush moveable along the sleeve, moving the rotor up and down; and a stationary ring with extended teeth faced toward the rotor. When the rotor is in its lower position the tubes engage the teeth and receive strikes which induce vigorous motion and effective mixing of media inside the tube. When the rotor is in its upper position the tubes are disengaged with the teeth and rotation of the rotor provides centrifugation of the media.

Automated device for homogenization and resuspension of substances, disintegration of cells, disruption of tissues and centrifugation of these media

The present invention relates to drug screening assays and methods for the treatment of proliferative disorders associated with elevated levels of heat shock protein 72 (Hsp72) expression in a cell. The invention is based on the discovery that overexpression of full length Hsp72 protein, or the C-terminal protein binding domain of Hsp72, results in oncogenic transformation of cells.

Screening methods for compounds useful in the regulation of cell proliferation

A multi-purpose device, the device including a tube holder for holding tubes; tube driving apparatus for rotating the tubes in the tube holder, the tube holder having spaces for accommodating the tubes such that each one of the tubes can be placed in a separate one of the spaces; the spaces having shapes and sizes providing free rotation of the tubes within the spaces about longitudinal axes of the tubes; the tube driving apparatus having touching engagement with walls of the tubes and pressing the walls of the tubes against the tube holder; and friction between the tube driving apparatus and the walls of the tubes being greater then friction between walls of the tubes and the tube holder.

Device for mixing, resuspending, homogenizing and aeration of substances in test tubes

Disclosed herein is a method for inducing Hsp72 production in a cell. The method involves contacting the cell transiently with a proteasome inhibitor in an amount sufficient to induce Hsp72 production. Preferably Hsp72 levels are induced to a level sufficient for the suppression of stress-activated kinase activity attributable, for example, to a stress-activated kinase selected from the group consisting of JNK and p38. The method has both in vitro and in vivo applications. Also disclosed is a method of the type described above is applied specifically to aged cells. Also disclosed is a method for treating pathologies associated with apoptosis and inflammation in an individual. The method involves administering to the individual a proteasome inhibitor in an amount sufficient to induce Hsp72 production. In a preferred embodiment of the therapeutic method, the individual is an aged individual. Stress-induced pathologies such as ischemia are particularly important with respect to the therapeutic aspect of the invention. Also disclosed is a method for identifying an organic compound having the ability to induce Hsp72 levels in aged cells to a level sufficient to suppress stress-activated kinase activity.

Hsp72 induction and applications

A mixer is intended for mixing substances, resuspending pellets and disintegrating living cells, such as yeast cells. The mixer includes a tube holder and an electric motor with striking attachment(s). The main part of the holder is rigid rings coaxial with and located subsequently along the motor shaft. Each ring has a number of holes the tubes sit in. Diameters of the holes are larger then diameters of the tubes, so that there are gaps between the tubes and the rigid rings. The attachment(s) of the motor is disks with blades, affixed to the motor shaft. When the motor shaft rotates the blades strike against the tubes. Struck tubes are repelled by the rigid ring (due to a gap between the tubes and rings), get a new strike from the blades and so on. As a result, the substance inside the tube receives a turbulent motion which provides mixing, resuspending and disintegrating effects.

Mixer having means for periodically mechanically striking

An auxiliary holder of tubes intended for disintegration of living cells, such as yeast cells, in the presence of glass beads, as well as for mixing substances and pellet resuspension. The holder is installed on a vibrator. Due to specially-made gaps between the tubes and the main parts of the holder the processed cells and substances are subjected to a complex impact of vibration created by the vibrator and shocks created by the holder. The holder strongly enhances the effectiveness of the vibrator. During the disintegrating process the presence of a researcher is not required.

Growing community of inventors

Newton, MA, United States of America

Michael Sherman