The Procter Gamble Company

Lonza Inc.

Michael Selden Godlewski

Graham John Myatt

Daniel Jerome White, Jr

Timothy Charles Gulbin

Patricia Ann Matson

William Lee Seibel

Yves Guggisberg

Randy Stuart Muth

Sean Rees Klopfenstein

Daniel Joseph Quarroz

Sreenivasa Reddy Mundla

Daniel Quarroz

Daniel Jerome White

A liquid pharmaceutical suspension for oral administration containing a bismuth-containing pharmaceutical agent, a suspension system, and water. The suspension system can contain from about 0.001% to about 0.2% gellan gum and from about 0.001% to about 0.75% magnesium aluminum silicate.

Bismuth containing liquid pharmaceutical suspensions

Process for making 1,3-disubstituted-4-oxocyclic ureas

The present invention provides a process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by preparing the corresponding activated 2-thio-subsituted-2-derivative in a two-step, one-pot procedure and by further reacting yields this isolated derivative with the appropriate amine or its salts in the presence of a proton source. The present process allows for the preparation of 2-amino-2-imidazolines, quanidines, and 2-amino-3,4,5,6-tetrahydropyrimidines under reaction conditions that eliminate the need for lengthy, costly, or multiple low yielding steps, and highly toxic reactants. This process allows for improved yields and product purity and provides additional synthetic flexibility.

Process for making 2-amino-2-imidazoline, guanidine and

Growing community of inventors

Loveland, OH, United States of America

Michael Selden Godlewski