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The Royal Institution for the Advancement of Learning / Mcgill University

Tsantrizos, Youla S.

Sebag, Michael

Michael Sebag

Youla S Tsantrizos

Richard Kremer

Ramy Saleh

Jiarong Li

Catalin Mihalcioiu

Novel C-2-substituted bicyclic compounds of Formula I have been prepared and found to be useful as inhibitors of by inhibiting geranylgeranylation of proteins.  The application is directed to these compounds, to compositions comprising these compounds and to their use, in particular as medicaments to cancer and other conditions treatable by inhibiting human geranylgeranylation pyrophosphate hGGPPS activity.

Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof

It is herewith provided methods of obtaining circulating cancer cells (CCCs)-enriched cellular populations based on the removal of CD45-positive cells from an apheresis product. It is also provided methods of obtaining circulating stem cells (CSCs)-enriched cellular population from a CCCs-enriched cellular population based on a selection either using the specific cellular markers or through culture. It is further provided methods of obtaining circulating tumor cells (CTCs)-enriched cellular population from a CCCs-enriched cellular population based on a selection using the specific cellular markers. It is also provided screening assays for the selection of (chemo)therapeutic agent as well as personalized medicine application based on drug sensitivity/resistance or cancer markers.

Method of obtaining circulating cancer cell populations

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Montreal, Canada

Michael Sebag