Xenon Pharmaceuticals Inc.

Genentech, Inc.

Michael Scott Wilson

Thilo Focken

Alla Yurevna Zenova

Christoph Martin Dehnhardt

Michael Edward Grimwood

Qi Jia

Jean-Christophe Andrez

Shaoyi Sun

Sultan Chowdhury

Brian Salvatore Safina

Ivan William Hemeon

Paul Robert Bichler

Kristen Nicole Burford

Philippe Bergeron

Shannon Marie Decker

Verner Alexander Lofstrand

Daniel P Sutherlin

Abid Hasan

Tao Sheng

Wei Gong

Daniel Fred Ortwine

Jun M Li

Steven Sigmund Wesolowski

Jiuxiang Zhu

Zhiguo Liu

Andrew D White

Chien-An Chen

David Earl Bogucki

Birong Zhang

Claudio F Sturino

Robert Joseph Devita

Kwong Wah Lai

Steven McKerrall

Ramsay Beveridge

Jean-Philippe Leclerc

Syed Abid Hasan

James Philip Johnson, Jr

James Roy Empfield

Charles Jay Cohen

Alexandre Lemire

Liang Zhao

James Philip Johnson

Jun Li

Jr Johnson James Philip

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents

Benzenesulfonamide compounds and their use as therapeutic agents

Benzenesulfonamide compouds and their use as therapeutic agents

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

This invention is directed to heteroaryl-substituted sulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors

The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y&#x2014;Y, R, R, R, R, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted triazolopyridines and methods of use thereof

The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, B, R, R, R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

N-substituted benzamides and methods of use thereof

Growing community of inventors

Burnaby, Canada

Michael Scott Wilson