Eli Lilly and Company

Michael Scott VanNieuwenhze

Larry C Blaszczak

Paul Luther Skatrud

William Joseph Hornback

Scott C Mauldin

Mohammad Sadegh Zia-Ebrahimi

William Ernest Alborn, Jr

Elizabeth Anne Dingess-Hammond

The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl-&#x3b2;-[1,4]-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation of GMDP and related compounds having a glucosaminyl-&#x3b2;-[1,4]-N-acetylmuramic acid disaccharide core.

Glycopeptide and preparation thereof

A process is described for preparing a substrate for the transglycosylase enzymes of bacterial cell wall biosynthesis. The chemical synthesis makes available a sustainable and substantially pure source of supply of lipid II, including analogs thereof, that may be used in the identification of new therapeutic agents capable of disrupting steps in bacterial cell wall biosynthesis.

Process for preparing lipid II

Growing community of inventors

Carlsbad, CA, United States of America

Michael Scott VanNieuwenhze