Other

Fluxion Biosciences, Inc.

Boston Scientific Scimed, Inc.

Michael Schwartz

Cristian Ionescu-Zanetti

Vladimir Schwartz

Klaus M Bierwagen

Daryush Mirzaee

Eric Williams

Jeff C Jensen

Michael Khenansho

Michelle Khine

Joshua Tanner Nevill

Andrew Blatz

Carolyn G Conant

Roger Rudoff

Doron Dagan

Ronald E Blazo

The invention discloses diagnostic techniques based on single cell genomics, consisting of obtaining a blood sample, enriching a sub-population of cells present in the blood sample, sequestering individual cells or group of cells from the blood sample, obtaining sequencing data from the sequestered cells or group of cells, using genetic variant information to determine the provenance of the cells, and genetically analyzing the cells of the correct provenance to provide a diagnostic readout. Using the cell-based testing techniques of the invention, the number of false positives is greatly reduced when compared to cell-free DNA (cfDNA) based traditional testing techniques. The invention may be effectively employed for non-invasive prenatal (NIPT) diagnostics, oncological testing and other diagnostic procedures.

Molecular characterization of single cells and cell populations for non-invasive diagnostics

Methods, microfluidic devices, and instruments for magnetic separation of particles from a fluid are described. Examples include microfluidic devices having a removable portion. Examples include microfluidic devices having one or more regions of reduced fluid velocity. Examples further including instruments having pneumatic interfaces. Examples further includes instruments having controllable magnets, imaging components, or combinations thereof.

Devices, systems, and methods for magnetic separation

The present invention refers to a crevice tool for vacuum cleaners as a singular component, comprising a socket transitioning into a long, flat air chamber, at an angle of approximately 45 degrees, wherein the air chamber (wand) incorporates both air suction slots and protruding nubs on both the top and bottom of the tool, and lateral slits in the end opposite the socket end. The various components of the crevice tool may be fabricated into kit form, and may include an adaptor, an extension, and a paw like terminal end, that can be used for removing any debris from tight areas.

Crevice tool for vacuum cleaners

An apparatus for treatment of a bifurcation of a body lumen, the bifurcation having a main vessel and a branch vessel, the apparatus includes a bifurcated balloon with a first branch portion and a second branch portion, the second branch portion including an inflatable portion adapted to extend toward the branch vessel, the bifurcated balloon also having a proximal shaft portion and a distal shaft portion connected to the inflatable portion of the second branch portion, and wherein the first branch portion and the second branch portion each have a longitudinal axis, the axis of the first branch portion being substantially parallel to the longitudinal axis of the second branch portion.

Catheter balloon systems and methods

Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic device. The apparatus provided includes a microfluidic device coupled to a multi-well structure and an interface for controlling the flow of media within the microchannel device.

Methods and apparatus for the manipulation of particle suspensions and testing thereof

A system and method for electro-forming a metal layer on a substrate. The system has a rotary jet planarizer in an electro-forming or galvanic cell. The cell includes a toroidally-shaped manifold with two inlets and an outlet. Each of the inlets is coupled to tubing from a sump assembly. Pressurized electrolyte flows from the sump assembly to the manifold. Directly downstream from the manifold is a diffuser having a plurality of openings. Electrolyte flows through the diffuser to an toroidally-shaped anode basket filled with metal pellets. After flowing through the anode basket, the electrolyte flows to a rotary jet planarizer. The planarizer has a rotatable plate with a main opening, a plurality of apertures radially extending from the main opening, and a conduit that is coupled to the main opening and extends out of the cell. A motor is coupled to the rotary jet planarizer to rotate the plate. The rotating plate directs the electrolyte to a cathode assembly in multiple streams so that the electrolyte washes evenly over a wide, ring-shaped area of a glass master held in a cathode assembly. A layer of metal is galvanically deposited on the glass master. Flow of electrolyte in the cell may follow one of two patterns: a radial pattern or a central pattern. Electrolyte may flow through two returns positioned adjacent to the rotary jet planarizer, one on each side of the cell or through the conduit coupled to the main opening in the plate. The two returns and conduit are coupled to the sump assembly, where the electrolyte is filtered and then pumped back to the cell.

System for forming nickel stampers utilized in optical disc production

An apparatus for the spin coating of substrates including a substrate carrier, a motor for rotating the substrate carrier, and a spinning bowl surrounding the substrate carrier. A lid is also provided in this spin coating apparatus which at least partially covers the spinning bowl for diminishing the escape for fumes into the ambient atmosphere during the spin coating of a substrate carried by the substrate carrier. The lid is also designed for improving the air flow around the substrate carried by the substrate carrier during the spin coating of the substrate.

Compact disc spin coater

A system and method for tracking compact discs during manufacture comprising a spindle having a central shaft and a base for carrying a plurality of compact discs, electronic memory storage system connected to the spindle, and data transfer means cooperating with the spindle to send and receive information identifying compact discs carried by the spindle and/or providing processing information about compact discs carried by the spindle from or to the electronic memory storage system.

Growing community of inventors

Oakland, CA, United States of America

Michael Schwartz