Basf Aktiengesellschaft

Basf Se Corporation

Abbott Laboratories Corporation

Abbvie Inc.

Abbvie Deutschland Gmbh and Co Kg

Basf Aktiengesllschaft

Michael Schulz

Peter Schwab

Ralf Schulz

Joaquim Henrique Teles

Ulrich Müller

Norbert Rieber

Wolfgang Harder

Boris Breitscheidel

Michael Slany

Georg Heinrich Grosch

Rolf Hartmuth Fischer

Alexander Weck

Karsten Eller

Marc Walter

Steffen Maas

Heiko Maas

Edgar Zeller

Carsten Oost

Anne Wenzel

Martin Sch&auml;fer

Justin Wolf

Horst Grafmans

Wolfram Stuer

Helmut Werner

Gunter Wahl

Jorg Sundermeyer

Jochem Henkelmann

Rolf Pinkos

Klaus Ebel

Ekkehard Schwab

Gerd Kaibel

Peter Bassler

Martin Fischer

Sean Colm Turner

Klemens Massonne

Achim Stammer

Michael Ochse

Anil Vasudevan

Werner Schnurr

Juergen Gert Tropsch

Jean-Marie Basset

Michael Röper

Laszlo Marosi

Achim Moeller

Maximilian Vicari

Ulrich M&uuml;ller

Arthur H&ouml;hn

Joachim Thiel

Karl-Heinz Ross

Heinz Auer

Arnd B&ouml;ttcher

Joachim Queisser

Martin Schmidt

Michael Roeper

Franz Josef Brocker

Martin Schäfer

Michael R&ouml;per

Jürgen Dinges

Andreas Walch

Dominic Vanoppen

Karl Fischer

Hans Hammer

Hans-Ulrich Jaeger

Gerald Meyer

Hermann Pütter

Jean Thivolle-Cazat

Heinz Ruetter

Sylvia Huber

J&uuml;rgen Tropsch

Karl-Heinz Roβ

Hans-Ulrich J&auml;ger

Stefan Quaiser

Elizabeth Louise Van Der Kam

Gert Treiber

Arthur Höhn

Heinz Rütter

J&uuml;rgen Dahlhaus

Jochen Kellenbenz

J&ouml;rn Karl

Ansgar Sch&auml;fer

Harald Wurz

Mostapha Taoufik

Jürgen Dahlhaus

Günther Grimm

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R, Rand Rare as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the &#x3b3;-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use

A process for preparing N,N-dimethylacetamide (DMAC) by continuously reacting methyl acetate (MeOAc) with dimethylamine (DMA) in the presence of a basic catalyst, wherein MeOAc is used in the form of a methanolic solution which is obtained as a by-product in the preparation of polyTHF by transesterifying polyTHF diacetate with methanol.

Method for the production of N,N-dimethylacetamide (DMAC)

A process for preparing N,N-dimethylacetamide (DMAC) by continuously reacting methyl acetate (MeOAc) with dimethylamine (DMA) in the presence of a basic catalyst, wherein MeOAc is used in the form of a methanolic solution and the continuous distillative workup is effected in such a way that methanol and any other low boilers are initially removed overhead in a column A and the bottom effluent of column A is fed to a column B in which DMAC is removed via a side draw a purity of &#x2267;99.7% by weight.

The invention describes a process for the preparation of novel surfactant alcohols and surfactant alcohol ethers by derivatization of olefins having from about 10 to 20 carbon atoms or of mixtures of such olefins to give alkanols, and optional subsequent alkoxylation, which comprises subjecting a C-olefin mixture to metathesis, dimerizing the resulting olefins, and then derivatizing them to give surfactant alcohols, and optionally alkoxylating said alcohols. The olefin mixture obtained in the dimerization has a high proportion of branched components and less than 10% by weight of compounds which contain a vinylidene group. invention further describes the use of the surfactant alcohols and surfactant alcohol ethers to give surfactants by glycosylation or polyglycosylation, sulfation or phosphation.

Process for the preparation of surfactant alcohols and surfactant alcohol ethers, the prepared products and their use

The invention relates to a method for producing hydrocarbons having a modified carbon skeleton by reacting aliphatic hydrocarbons a) with themselves, b) with another aliphatic hydrocarbon or c) with aromatic alkyl substituted hydrocarbons, in the presence of a metal organic catalyst or the hybrid thereof, at a temperature of between 20&#x2013;400&#xb0; C. and a pressure of between 0.2&#x2013;100 bars, wherein the reaction takes place in the presence of hydrogen.

Method for producing hydrocarbons having a modified carbon skeleton

A description is given of a process for preparing methyl formate by reacting excess methanol with carbon monoxide under superatmospheric pressure and at elevated temperature in the presence of alkali metal methoxide or alkaline earth metal methoxide as catalyst in a pressure-rated reactor, in which the use of at least two reactor elements, preferably operated in countercurrent, at about 100&#xb0; C. and a pressure of about 100 bar in combination with a solids-free desalting of the reaction product makes possible very economical, largely trouble-free production of methyl formate in any desired quality and with a very good production capacity. Furthermore, the process for solids-free desalting and apparatuses for carrying out this process are described.

Method for the continuous production of methyl formate

The invention relates to a catalyst system for carbonylating olefinically or acetylenically unsaturated compounds with carbon monoxide and a nucleophile compound, containing (a) palladium; (b) a phosphine and (c) a polymer containing nitrogen which is soluble in the reaction mixture, with the exception of polyvinyl polymers with aromatic radicals containing nitrogen on the polymer chain. The invention also relates to a method for carbonylation in the presence of one such catalyst system.

Catalyst system and method for carbonylation

Propene and, if desired, 1-butene are prepared by

Preparation of propene and, if desired, 1-butene

Method for producing surfactant alcohols and surfactant alcohol ethers, the resulting products and their use

A multistage process for preparing propene, in which the first stage is the reaction of 1-butene, 2-butene and isobutene to give propene, 2-pentene and 2-methyl-2-butene in the presence of a metathesis catalyst comprising at least one compound of a metal of transition group VIb, VIIb or VIII of the Periodic Table of the Elements; the second stage is separation of the propene and 2-pentene/2-methyl-2-butene formed; the third stage is reaction of the 2-pentene and 2-methyl-2-butene with ethehe to give propene, 1-butene and isobutene in the presence of a metathesis catalyst comprising at least one compound of a metal of transition group VIb, VIIb or VIII of the Periodic Table of the Elements; the fourth stage is separation of the propene and 1-butene/isobutene formed and returning the 1-butene and isobutene formed to the first stage.

Preparation of propene

Preparation of C5-/C6-olefins

Method for oxidizing an organic compound containing at least one C-C double bond

Preparation of substituted olefins

Cationic ruthenium complexes, their production and their use

In the process for preparing formamide by reaction of ammonia and carbon monoxide in the presence of at least one catalyst, sodium diformylamide is used as catalyst. If sodium methoxide is used as further active component, sodium diformylamide can be formed from this. In this process, sodium diformylamide is a particularly active and stable catalyst which can be recycled.

Production of formamide using sodium diformylamide

Growing community of inventors

Ludwigshafen, Germany

Michael Schulz