Hoffmann-la Roche Inc.

Roche Diagnostics Operations, Inc.

Michael Schraemi

Olaf Mundigl

Christian Scholz

Hans-Willi Krell

Ulrich Goepfert

Michael Gerg

Herbert Andres

Valeria Lifke

Fiona Grueninger

Hartmut Duefel

Sonja Offner

Bernd Bohrmann

Walter Huber

Frank Kowalewsky

Laurence Ozmen

Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.

Antibody specifically binding to insulin-like growth factor-1

An antibody binding to Tau that is phosphorylated at serine 422 (pS422), which specifically binds to phosphorylated Tau fragment of SEQ ID NO:9 and to Tau pS422, but does not bind to Tau and to phosphorylated MCAK fragment of SEQ ID NO:17. The antibody is useful in the treatment of a Tauopathy.

Use of an anti-Tau pS422 antibody for the treatment of brain diseases

Growing community of inventors

Penzberg, Germany

Michael Schraemi