Chemspeed Technologies Ag

Dsm IP Assets B.v.

Roche Vitamins Inc.

Michael Schneider

Werner Bonrath

Thomas Thaler

Thomas Netscher

Jonathan Alan Medlock

Rolf Gueller

Reinhard Karge

Markus Schindler

Detlef Eisenkraetzer

Josef Schröer

Daniel Juchli

Annie Schnyder

Christoph Moor

Valerie Enjolras

Markus Schinder

A metering apparatus including a scale on which a metering head is disposed in such a manner that the scale measures the weight of the metering head, and a metering tool for taking up and dispensing substance, attached to the metering head. The metering tool is configured as a glass tubule having a glass punch slidably disposed therein, forming a seal. The metering head is provided with a first gripping tool for clamping the glass tubule in place and with a second gripping tool for clamping the glass punch in place. The metering head furthermore has a raising and lowering device for raising and lowering the second gripping tool relative to the first gripping tool, such that the glass punch can be raised and lowered in the glass tubule of the metering tool.

Metering apparatus

A container for taking up and dispensing a substance includes a glass tubule, a glass punch that slides adjustably in the glass tubule, forming a seal, and a glass sleeve closed on one side, in which the glass tubule is accommodated. The glass sleeve is shorter than the glass tubule, so that the glass tubule projects out of the glass sleeve. The glass punch is longer than the glass tubule and projects out of the glass tubule at the end situated outside of the glass sleeve. The glass punch does not fill the glass tubule completely, so that a substance chamber remains in the region of the end of the glass tubule situated within the glass sleeve.

Substance container

Disclosed is a method for carrying out a chemical reaction in a reactor, at least one substance is present in a container that is closed in a gas-tight manner, is introduced into the reactor in said container and is released by breaking open the container. The container is designed such that it breaks open when a specified bursting pressure difference between the internal pressure and external pressure is exceeded. The container is broken open and the substance located in the container is thus released as a result of deliberate application in the reactor of a pressure difference exceeding the bursting pressure difference.

Substance container for a chemical reaction

A device for dosage of substances having a substance intake portion, which included at least one substance compartment for the intake of substance to be dosed, an emptying portion for the emptying the substance compartment and a weighing balance for the determination of the quantity of dosed substance, wherein the substance intake portion includes a plurality of substance compartments, which are able to be individually emptied. The device further includes a control means, which control the emptying of the substance compartments in a manner dependent on the quantity of dosed substance, which is determined by means of the weighing balance.

Device for dosage of substances

A process for the manufacture of 2,3,5-trimethylhydroquinone diacylate comprising reacting ketoisophorone with an acylating agent in the presence of a NH- or CH-acidic catalyst, particularly certain bis(perfluorinated hydrocarbyl sulphonyl) imides and metal salts thereof and, respectively, certain tris(perfluoroalkanesulphonyl or pentafluorobenzenesulphonyl) methanes and metal salts thereof. The acylating agent is particularly an acid anhydride, an acyl halide or an enol ester. The so-obtained 2,3,5-trimethylhydroquinone diacylate can be converted into (all-rac)-&#x3b1;-tocopherol by transesterification to yield 2,3,5-trimethylhydroquinone and reaction of the latter with isophytol. (all-rac)-&#x3b1;-Tocopherol itself is the most active member of the vitamin E group.

Manufacture of trimethylhydroquinone diacylates

The present invention is a process for converting trimethylhydroquinone diacetate (TMHQ-DA) into trimethylhydroquinone-1-monoacetate (TMHQ-1-MA) by contacting TMHQ-DA with a lipase to effect an enzymatic monosaponification of the TMHQ-DA. Also provided are methods of making (all-rac)-&agr;-tocopherol and (all-rac)-&agr;-tocopherol acetate.

Process for the manufacture of a vitamin E intermediate

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Frick, Switzerland

Michael Schneider