Medtronic Vascular, Inc.

Medtronic, Inc.

Stokes Bio Limited

Michael Sayers

Marc A Anderson

Aram Jamous

Mark Davies

John Kelly

Kieran Curran

Tara Dalton

Brian Dowling

Eamon Keane

Shane Nolan

Matthew Fleming

Tomas K Kelly

Cian Ryan

Brian T Chawke

Lana Woolley

Bryan Hansen

Damian Michael Curtin

Brian Barrett

Noel Sirr

Jonathan Ashley Cope

Risa Tom Egerter

Ryan J Talbot

David J Hobbins

Mauro Aguanno

Conor O'Donovan

Mick Donegan

Ronan Finn

Eoin J Walsh

Shane Cooney

David Kinahan

Cian Walsh

Damien King

Niall Kelly

Damian Cunniffe

Tommy Hayden

John Clifford

Mark Korenke

Xiaona Hou

David Mcguire

A tissue-removing catheter for removing tissue in a body lumen includes a catheter body assembly having an axis and proximal and distal end portions spaced apart from one another along the axis. At least a portion of the catheter body assembly is sized and shaped to be received in the body lumen. A handle is mounted to the proximal end portion of the catheter body assembly and operable to cause rotation of the catheter body assembly. The handle includes internal handle components that interface with the catheter body assembly. The internal handle components provide at least four interface locations spaced axially along the catheter body assembly. A tissue-removing element is mounted on the distal end portion of the catheter body assembly. The tissue-removing element is configured to remove the tissue as the tissue-removing element is rotated by the catheter body assembly within the body lumen.

Tissue-removing catheter

Methods and apparatus are disclosed for customizing an elution rate of a stent. The stent includes a hollow strut that forms the stent, the hollow strut defining a lumenal space, a drug formulation disposed within the lumenal space of the hollow strut, and at least one side port for eluting the drug formulation in vivo. When the stent is in the radially expanded configuration the hollow strut is deformable from a first configuration that has a first elution rate for the drug formulation to a second configuration that has a second elution rate for the drug formulation. The second elution rate is faster than the first elution rate. The hollow strut deforms from the first configuration to the second configuration upon application of an applied pressure above a predetermined threshold.

Drug-eluting stent formed from a deformable hollow strut for a customizable elution rate

Methods and apparatus are disclosed for customizing an elution profile of a stent after manufacture of the stent has been completed. The stent includes a plurality of side ports for eluting a drug formulation within a lumenal space of a hollow strut that forms the stent. An effective diameter of at least one side port of the plurality of side ports of the stent is modified in order to customize an elution profile of the stent. In an embodiment hereof, the plurality of side ports are completely blocked or plugged with a filler material during the manufacture of the stent and at least a portion of the filler material is removed to increase an effective diameter of at least one side port of the plurality of side ports of the stent in order to customize an elution profile of the stent. In another embodiment hereof, the plurality of side ports are open following the manufacture of the stent and at least one side port of the plurality of side ports of the stent is at least partially filled with a filler material to decrease the effective diameter of the at least one side port in order to customize an elution profile of the stent. In another embodiment hereof, the stent is soaked within a liquid to remove at least a portion of the drug formulation from the lumenal space of the hollow strut to thereby customize an elution profile of the stent.

Customizing the elution profile of a stent

Growing community of inventors

Limerick, Ireland

Michael Sayers