Qorvo US, Inc.

Beckman Coulter, Inc.

Michael Salvati

Hashem Akhavan-Tafti

Renuka De Silva

Ian Robert Harmon

Wenhua Xie

James D Mendoza

Bruce H Odegaard

Dean G Binger

Nir Shapir

Ying Chen

Terri McLernon

Dean Binger

Terri Mclernon

Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.

Solution phase homogeneous assays

Sensitivity of thin film bulk acoustic resonance (TFBAR) sensors is enhanced by mass amplification and operating a high frequency.

Thin film bulk acoustic resonator with signal enhancement

Redox of an analyte is coupled with redox of a precipitation precursor to generate a precipitating molecule that precipitates on the surface of a thin film bulk acoustic resonance (TFBAR) to allow mass detection of the precipitation molecule as a surrogate for the analyte. This disclosure describes, among other things, detection of an analyte using a TFBAR operating at a high frequency without direct binding of the analyte on a surface of the TBAR. Detection of the analyte is indirect with a precipitating molecule serving as a surrogate for the analyte.

Mass detection through redox coupling

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Minnetrista, MN, United States of America

Michael Salvati