Johns Hopkins University

Michael S Yu

James Edward West

Dawnielle Farrar

Allen Yi-Lan Wang

Jennifer H Elisseeff

Ilene J Busch-Vishniac

Kailiang Ren

Hyeseung Janice Lee

Xiao Mo

Martin Gilbert Pomper

Catherine Anne Foss

Yang Li

Wonkyu Moon

Sangkyu Lee

Daniel Summerfield

The present invention provides both a caged collagen mimetic peptide (CCMP) having the formula: L-S-Z-[Gly-X-Y]-Gly-X-Y-[Gly-X-Y](SEQ ID NO:); wherein L is one or more detectable moieties; S is one or more spacer molecules; Zis any amino acid where m is an integer of 1 to 10; X is proline or modified proline; Y is proline or modified proline; Gly is glycine; n is an integer from 1 to 20; andGly is a glycine covalently linked to a cage moiety comprising a labile protecting group, as well as a collagen mimetic peptides lacking the labile protecting group (CMP). The inventions are useful for binding collagen and denatured collagen and/or gelatin both in vitro and in vivo, and are useful for targeting any organ or tissue where collagen is present, and can be used for research and diagnostic imaging (both in vivo and in vitro) and also for in vivo therapeutic applications.

Collagen mimetic peptides for targeting collagen strands for in vitro and in vivo imaging and therapeutic use

A piezoelectric, poly (&#x3b3;-benzyl-&#x3b1;,L-glutamate) ('PBLG') planar microphone, and method for construction thereof, are disclosed. The microphone includes at least a polyester film, a piezoelectric, hot pressed poly (&#x3b3;-benzyl-&#x3b1;,L-glutamate) ('HPPBLG') layer, and an aluminum coating for the HPPBLG layer. The coated HPPBLG layer is coupled to the polyester film.

PBLG based planar microphones

Piezoelectric compositions are provided wherein mechanical and piezoelectric properties can be separately modulated. Preferred compositions include resin blends that comprise: (a) a piezoelectrically active polymer and (b) a matrix polymer, methods of making, and use of such resin blends. Advantages of preferred resin blends of the invention can include high piezoelectricity, mechanical strength and flexibility, convenient fabrication process, and high sensitivity at high temperatures.

Piezoelectric compositions

A continuous piezoelectric film can include a plurality of fibers, each fiber including a polypeptide, wherein molecules of the polypeptide have electric dipole moments that are aligned such that the piezoelectric fiber provides a piezoelectric effect. The continuous piezoelectric film has at least one piezoelectric constant dor dthat is at least 1 pC/N. The continuous piezoelectric film can be prepared hot pressing a mat of aligned piezoelectric fibers.

Continuous piezoelectric film including polar polymer fibers

Piezoelectric fibers include a polypeptide wherein molecules of the polypeptide have electric dipole moments that are aligned such that the piezoelectric fiber provides a piezoelectric effect at an operating temperature. A piezoelectric component provides a plurality of piezoelectric fibers, each comprising an organic polymer. A method of producing piezoelectric fibers includes electrospinning a polymer solution to form a fiber and winding the fiber onto a rotating target in which the rotating target is electrically grounded. An acoustic sensor includes a plurality acoustic transducers, wherein the plurality of acoustic transducers are structured and arranged to detect a corresponding plurality of vector components of an acoustic signal, and at least one of the plurality of acoustic transducers comprises a piezoelectric fiber.

Piezoelectric polymer fibers

The invention provides modified collagen and related therapeutic and diagnostic methods.

Growing community of inventors

Timonium, MD, United States of America

Michael S Yu