The Brigham and Women's Hospital, Inc.

Precision Medical Devices, Inc.

Michael S Wolfe

Peter H Sayet

Lloyd A Sutherland

Dennis J Selkoe

Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors have sequences with lengths from 11 to 16 amino acids, inclusive. These inhibitors potently inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-&#x3b2;-peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat &#x3b2;-amyloid-associated diseases, notably Alzheimer's disease.

Helical peptidomimetics with enhanced activity

A biopsy device includes a housing and at least one biopsy mechanism moveably connected to the housing. The biopsy can be provided on a biopsy arm. An actuator moves the biopsy arm and operates the biopsy mechanism. The biopsy arms with the biopsy mechanisms are preferably removable from the housing, such that the housing can be used again for subsequent biopsy procedures.

Biopsy device

Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors preferably inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-&#x3b2; peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat &#x3b2;-amyloid-associated diseases, notably Alzheimer's disease.

Helical peptidomimetics

Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-&bgr; peptide. Methods are provided for administering the novel compounds to treat &bgr;-amyloid-associated diseases, notably Alzheimer's disease.

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Newton, MA, United States of America

Michael S Wolfe