Merck + Co., Inc.

Michael S Schwartz

Gerald E Stokker

Ta J Lee

Kenneth E Wilson

Henry Joshua

Steven M Pitzenberger

Suresh K Balani

Harri G Ramjit

Anthony Y Lu

Novel dipeptide isosteres are the biotransformed products after incubation with rat liver slices. They inhibit HIV protease, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts (when appropriate), pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Method of preparing HIV protease inhibitors

Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.

3-keto HMG-CoA reductase inhibitors

3-keto HMG-COA reductase inhibitors

Growing community of inventors

Glenside, PA, United States of America

Michael S Schwartz