University of California

Neuvivo, Inc.

Pathologica LLC

Michael S Mcgrath

Vernon A Norviel

Arasteh Ari Azhir

Bruce D Forrest

Kenneth G Hadlock

Leah Price

Provided herein are methods and compositions for the treatment of ALS using chlorite or a pharmaceutical composition comprising sodium chlorite, for a target ALS patient population. Also provided herein are methods for identifying a target ALS patient population likely to be responsive to treatment with chlorite or a pharmaceutical composition comprising sodium chlorite, the methods including identifying ALS patients with elevated plasma C-reactive protein (CRP) levels and/or patients age 40-65, sporadic ALS pathology, or combinations thereof.

Treatment methods for ALS patients

Described herein are methods of monitoring and treating a subject with ALS based on biomarkers.

Biomarkers for neurogenerative disease

The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia (A-T), or neurodegenerative diseases such as Parkinson's disease or neuropsychiatric diseases comprising administering to a subject in need thereof an effective amount of chlorite composition, such as sodium chlorite. The present invention thereby provides a method of modulating the immune system in a subject in need thereof. Described herein are methods of administration and treatment.

Treatment of neurodegenerative disease with sodium chlorite

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Meadow Vista, CA, United States of America

Michael S Mcgrath