University of Washington

Michael S Grow

Sinclair S Yee

Clement E Furlong

Peter C Kauffman

Timothy M Chinowsky

Scott D Soelberg

Jared Tritz

Alexei N Naimushin

Yongmin Kim

Donglok Kim

Weiyun Sun

Stefan G Berg

This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

Portable and cartridge-based surface plasmon resonance sensing systems

The register file of a processor includes embedded operand queues. The configuration of the register file into registers and operand queues is defined dynamically by a computer program. The programmer determines the trade-off between the number and size of the operand queue(s) versus the number of registers used for the program. The programmer partitions a portion of the registers into one or more operand queues. A given queue occupies a consecutive set of registers, although multiple queues need not occupy consecutive registers. An additional address bit is included to distinguish operand queue addresses from register addresses. Queue state logic tracks status information for each queue, including a header pointer, tail pointer, start address, end address and number of vacancies value. The program sets the locations and depth of a given operand queue within the register file.

Operand queues for streaming data: A processor register file extension

Growing community of inventors

Seattle, WA, United States of America

Michael S Grow