Bristol-myers Company

Bristol-myers Squibb Compnay

Bristol-myers

Michael S Eison

Joseph P Yevich

Ronald J Mattson

Povl Krogsgaard-Larsen

Davis L Temple

Christopher G Boissard

Stacy N Suberg

Duncan P Taylor

Michael F Rafferty

A process for protecting brain cells from ischemia and for treating ischemic and degenerative brain disorders. The process involves systemic administration of BMY 14802 or a pharmaceutically acceptable acid addition salt and/or hydrate.

Method of treatment of ischemia in brain

Tetrahydro-isoxazolo[4,5-d]azepine derivatives possess antiamnesic properties and are cognition enhancers.

THAZ derivatives for enhancement of cerebral function

Tiospirone and its pharmaceutically acceptable salts are useful in alleviation of vascular or vascular-related headaches such as migraine, cluster, muscle-contraction, and combined headaches.

Method for alleviation of vascular headache

A series of diazinylpiperidine compounds of Formula I ##STR1## wherein X is an ethylene chain or a 1,2-benzo ring; Y is carbonyl or methylene; R.sup.1 is hydrogen or lower alkyl; and Z is an R.sup.2, R.sup.3 -disubstituted diazinyl ring selected from pyridazine, pyrimidine, and pyrazine ring systems. Pharmacologic and neuroanatomical testing demonstrates that compounds of the series act to enhance cerebral function in mammals, particularly when there is a deficit in normal cerebral functioning. Specific pharmacologic test results indicate that compounds of Formula I possess cognition and memory enhancing activity.

Cerebral function enhancing diazinylpiperidine derivatives

Growing community of inventors

Avon, CT, United States of America

Michael S Eison