Phaserx, Inc.

Genevant Sciences Gmbh

University of Washington

Michael S DeClue

Charbel Diab

Sean D Monahan

Mary Gallagher Prieve

Pierrot Harvie

Maher Qabar

Anna Galperin

Debashish Roy

Amber E Paschal

Russell N Johnson

Michael E Houston, Jr

Allan Sachs Hoffman

Patrick S Stayton

Anna S Gall

Paul Hickok Johnson

Priyadarsi De

Robert W Overell

Amber E E Paschal

Michael E Houston

Paul H Johnson

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Nucleic acid constructs and methods of using the same

Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Multiblock copolymers

Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.

Targeting monomers and polymers having targeting blocks

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Seattle, WA, United States of America

Michael S DeClue