California Institute of Technology

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Thermo Fisher Scientific (bremen) Gmbh

University of California

Michael Roukes

Hongxing Tang

Edward B Myers

Michael C Cross

Matthew H Matheny

Rassul Bulatovich Karabalin

Scott E Fraser

Blake Waters Axelrod

Chung Wah Fon

Jessica L Arlett

Jerry E Solomon

Alexander Alekseevich Makarov

Mo Li

Igor Bargatin

John Sequoyah Aldridge

Chung-Wah Fon

Luis Guillermo Villanueva Torrijo

Wonhee Lee

Laurent Duraffourg

Philippe Andreucci

Pierre Puget

Benjamin Gudlewski

Sotirios Masmanidis

Seyed Ali Hajimiri

Nathan S Lewis

Andrei Faraon

James R Heath

Dmitry E Grinfeld

Eric Colinet

Thomas Ernst

Sebastien Hentz

Sébastien Hentz

Mehmet Selim Hanay

John Liang Tan

Akshay Naik

Ewa Rej

Philip X-l Feng

Sotiris K Masmanidis

Jiangang Du

Gilles J Laurent

Heather McCaig

Xiao-Li Feng

Geoffrey Nunes

Christopher John White

Guillaume Delapierre

Eric Wapelhorst

Inna Kozinsky

Yanxia Hou-Broutin

Yuri Bunimovich

Carine Marcoux

David D Awschalom

Akram Sarwat Sadek

Peter Willis

Pierre Brianceau

Darron K Young

Roland K Kawakami

Derrick Chi

Hong X Tang

Guanglu Ge

John Nagarah

Scott Kelber

Kamil L Ekinci

Trevor M Fowler

Kristen Beverly

P Chris Hammel

Denis V Pelekhov

Michael J Murphy

Franklin G Monzon

Melissa M Midzor

Harpreet Singh Arora

Ron Lifshitz

Keith C Schwab

Mikhail Skoblin

Warren Fon

Stephane Minoret

Paula Popescu

Luis Guillermo Villanueva

Eyal Kenig

Raj M Katti

Maria Reinhardt-Szyba

Richard Renaud

Stevan Nadj-Perge

Eran Segev

Philip Xiaoli Feng

Laurent Moreaux

Rassul Karbalin

James Maloney

Stéphane Minoret

An electrostatic ion trap or an array of electrostatic ion traps are provided having a longitudinal length of no more than 10 mm and/or at least one electrode with a capacitance to ground of no more than 1 pF. First and second sets of planar electrodes may be distributed along the longitudinal axis, at least some of the which are configured to receive an electrostatic potential for confinement of ions received in the space between the first and second sets of planar electrodes. An array may comprise an inlet for receiving an ion beam, configured such that a portion of the ion beam can be trapped in each of the ion traps. Signals indicative of ion mass and charge data may be obtained from multiple electrostatic ion traps in the array. This mass and charge data may be combined for identification of components of a mixture of different analyte ions.

Electrostatic ion trap configuration

A graphene-based broadband radiation sensor and methods for operation thereof are disclosed. The radiation sensor includes an electrical signal path for carrying electrical signals and one or more resonance structures connected to the electrical signal path. Each resonance structure includes a resonator having a resonant frequency. Each resonance structure also includes a graphene junction connected in series with the resonator, the graphene junction including a graphene layer and having an impedance that is dependent on a temperature of the graphene layer. Each resonance structure further includes a heating element that is thermally coupled to the graphene layer and is configured to receive an incident photon, where the temperature of the graphene layer increases in response to the heating element receiving the incident photon.

Broadband radiation sensor based on a resonantly-coupled graphene SNS junction

A NEMS readout system includes a sensor array comprising a plurality of sensors. Each sensor of the plurality of sensors including a resonator with frequency characteristics different from the resonator of each other sensor of the plurality of sensors. A readout signal indicative of a plurality of output signals is collected from the sensor array. Each output signal of the plurality of output signals corresponding to one of the plurality of sensors. An analysis of the plurality of output signals is performed to identify a plurality of resonant frequencies and to detect a frequency shift associated with at least one of the plurality of resonant frequencies.

Highly-multiplexed NEMS-array readout system based on superconducting cavity optomechanics

A nanoelectromechanical systems (NEMS) oscillator network and methods for its operation are disclosed. The NEMS oscillator network includes one or more network inputs configured to receive one or more input signals. The NEMS oscillator network also includes a plurality of NEMS oscillators coupled to the one or more network inputs. Each of the plurality of NEMS oscillators includes a NEMS resonator and produces a radio frequency (RF) output signal that oscillates at a particular frequency and a particular phase. The NEMS oscillator network further includes a plurality of connections that interconnect the plurality of NEMS oscillators. The NEMS oscillator network further includes one or more network outputs coupled to the plurality of NEMS oscillators and configured to output one or more output signals.

Nanomechanical networks for computation

The present invention relates to a system for analyzing particles, the system comprising: a NEMS device comprising at least one NEMS sensor for detecting particles impacting the at least one NEMS sensor, each NEMS sensor comprising a NEMS sensor area, a particle lens assembly, the particle lens assembly comprising at least one particle lens for focusing particles onto a NEMS sensor of the at least one NEMS sensor, wherein the particle lens assembly is spaced from the at least one NEMS sensor area by a separation distance, wherein the system is configured to sustain a space defined between the particle lens assembly and the NEMS device at a pressure where a mean free path for a reference particle is greater than the separation distance. The present invention also relates to a corresponding method.

System to analyze particles, and particularly the mass of particles

Method and apparatus for illuminating and imaging tissue is provided. In one version, the method includes illuminating a volume of a tissue with photons from a three-dimensional array of optical emitters inserted into the tissue. In another version, the method includes detecting photons from a volume of a tissue using a three-dimensional array of optical detectors inserted into the tissue. A probe device for illuminating tissue and/or detecting photons emitted from tissue includes elongated microsized probes containing optical emitters and optical detectors in a three dimensional array.

Brain-machine interface based on photonic neural probe arrays

A neural probe for light stimulation of a tissue is provided. The probe includes a base that has light supplying circuitry, and one or more elongated microsized shanks extending from the base. Each shank has a longitudinal axis and includes one or more waveguides extending along the shank's length, with the waveguides being optically connected to the light supplying circuitry. In addition, each of the waveguides is optically connected to a diffraction grating coupler that emits a light beam from the shank when light passes from the base through the waveguide and to the diffraction grating coupler. The emitted light beam has a propagation direction at a set angle relative to an axis that is substantially normal to the longitudinal axis of the shank. A method for stimulating a tissue using the neural probe is also provided.

Implantable, highly collimated light-emitters for biological applications

A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (NEMS-MS) system, a second mass spectral system including at least one mass analyzer adapted to separate the charged particles according to their mass-to-charge ratios, and an integration zone coupling the first and second mass spectral systems, the integration zone including at least one directional device for controllably routing the ions to a selected one or both of the first and second mass spectral systems for analysis thereby. The second system can be an orbital electrostatic trap system. The ion beam can be electrically directed to one or the other system by ion optics. A chip with resonators can be used with cooling. Uses include analysis of large mass complexes found in biological systems, native single molecule analysis, and size and shape analysis.

Integrated hybrid NEMS mass spectrometry

A device for analyzing a fluid, including a layer including a plurality of sensors of MEMS and/or NEMS type, a layer including a mechanism controlling the sensor and for processing information transmitted by the sensors, the control and processing mechanism being electrically connected to the detectors, and a layer positioned on the layer including the sensors on a side of a face including the sensors including a mechanism spatially and temporally distributing the fluid on the sensors.

Analysis device including a MEMS and/or NEMS network

An article comprising: an array of calorimeter devices, wherein the device comprises: at least one fluidic enclosure disposed on a microfluidic chip, wherein the fluidic enclosure is substantially gas impermeable; at least one first chamber and at least one second chamber, wherein the first chamber and the second chamber are disposed within and enclosed by the fluidic enclosure, wherein the first chamber and the second chamber are not vacuum encapsulated; at least two microfluidic channels connected to the first chamber and at least two microfluidic channels connected to the second chamber; and at least one thermal sensor disposed between the chip and the first and second chambers, wherein the thermal sensor is adapted to measure a temperature differential between the first and second chambers. Examples include DSC and TSA devices. Biological binding and melting experiments can be done with high sensitivity.

Nanoscale calorimeter on chip and related methods and devices

A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system.

System for analyzing a gas mixture including at least one chromatography column

Synchronization of oscillators based on anharmonic nanoelectromechanical resonators. Experimental implimentation allows for unprecedented observation and control of parameters governing the dynamics of synchronization. Close quantitative agreement is found between experimental data and theory describing reactively coupled Duffing resonators with fully saturated feedback gain. In the synchonized state, a significant reduction in the phase noise of the oscillators is demonstrated, which is key for applications such as sensors and clocks. Oscillator networks constructed from nanomechanical resonators form an important laboratory to commercialize and study synchronization&#x2014;given their high-quality factors, small footprint, and ease of co-integration with modern electronic signal processing technologies. Networks can be made including one-, two-, and three-dimensional networks. Triangular and square lattices can be made.

Synchronization of nanomechanical oscillators

A neural probe includes at least one shaft, at least one first electrode disposed on a first side of the at least one shaft, and at least one second electrode disposed on a second side of the at least one shaft. The at least one second electrode is separately addressable from the at least first electrode.

Method of making micromachined neural probes

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Pasadena, CA, United States of America

Michael Roukes