Brandeis University

Michael Rosbash

Weijin Xu

Hua Jin

Aoife McMahon

Isaac Edery

Hyung-jae Jung

Fang Guo

Francoise Stutz

Zuoshi Josh Huang

The present invention features fusion polypeptides comprising an RNA binding polypeptide operationally linked to an RNA modifying enzyme (e.g., adenosine deaminase, cytidine deaminase), and methods of use therefore.

Compositions and methods for identifying RNA binding polypeptide targets

The present invention features compositions comprising fusion polypeptides comprising an RNA binding polypeptide operationally linked to an RNA modifying enzyme (e.g., adenosine deaminase, cytidine deaminase), and methods of use therefore.

Systems and methods for monitoring and controlling activities oforganisms are provided. In one aspect, a method includes acquiring, using a first activity detector, imaging data tracking movements of theorganisms, and acquiring, using a second activity detector, bioluminescence data corresponding to a neural activity of theorganisms. The method also includes correlating, using the acquired data, a behavioral activity and neural activity of theorganisms, and determining, using the correlation, an activity profile for theorganisms. The method further includes providing, based on the activity profile, a stimulation to theorganisms to control at least one of the behavior activity or the neural activity over a time period extendible to a nominal life cycle of theorganisms.

Systems and methods for monitoring and controlling drosophila activity

A novel conserved amino acid motif ('PAS') which provides a binding site for homo and hetero protein interactions has been found in mammalian and insect proteins. Abnormalities in these protein interactions are believed to be responsible for a variety of human diseases or conditions, including behavioral disorders and epithelial tissue cancers. Methods for identifying persons who have a disposition towards these behavioral disorders or epithelial tissue cancers are described. Methods are also described for identifying agonists and antagonists of proteins or related peptides containing PAS domains. Screening such agents involves assessing the ability of candidate compounds to promote or interfere with the binding of certain biologic preparations comprised of PAS-containing proteins. Successful agonists or antagonists should be useful in modifying the effects of human behavioral disorders, as well as certain epithelial cancers.

PAS domain proteins

Methods of identifying and screening for agents with biological activity against target molecules using yeast cell cultures are described.

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Waltham, MA, United States of America

Michael Rosbash