Biotest Ag

Michael Rodemer

Dieter Rudnick

Oliver Maneg

Matthias Germer

Veit Braun

Wolfgang Möller

Wolfgang Moeller

Eckhard Flechsig

Herbert Dichtelmueller

An antibody preparation suitable for intravenous administration in humans includes IgG, IgA and at least 5% IgM antibodies by weight of the total amount of antibodies. The preparation is prepared from human plasma, has specific complement activating activity, and, in an in vitro assay with human serum suitable to determine the ability of the antibody preparation to activate complement unspecifically, the antibody preparation generates substantially no C5a and/or substantially no C3a. The antibody preparation can have medical uses.

Methods of treating viral infections by administering an antibody preparation comprising IGG, IGA and IGM

IgG, IgA and IgM antibody preparations, method of making and method of use in treatment

An antibody preparation suitable for intravenous administration in humans includes IgG, IgA and at least 5 % IgM antibodies by weight of the total amount of antibodies. The preparation is prepared from human plasma, has specific complement activating activity, and, in an in vitro assay with human serum suitable to determine the ability of the antibody preparation to activate complement unspecifically, the antibody preparation generates substantially no C5a and/or substantially no C3a. The antibody preparation can have medical uses.

Antibody preparations

A process is provided for the preparation of an immunoglobulin composition from a plasma fraction having immunoglobulins, and antibody preparations prepared utilizing the process.

Process for preparing an immunoglobulin composition

Growing community of inventors

Rodgau, Germany

Michael Rodemer