Sirna Therapeutics, Inc.

Ezshield, Inc.

Michael Robinson

Duncan F Brown

Steven Bartz

John C Browning

Pradip Sitaram

Steve Bartz

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of HBV gene expression and/or activity, and/or modulate a HBV gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against HBV gene expression.

RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (SINA)

RNA interference mediated inhibition of hepatitis B Virus (HBV) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)

A method includes creating an electronic record of an asset, and automatically associating a predefined data structure with an electronic record of the asset that controls organization and display of user provided metadata describing the asset. The method may also include receiving the metadata describing the asset from a remote computer, populating the predefined data structure with the metadata describing the asset, and generating a graphical user interface corresponding to the electronic record of the asset with active tabs that provide a visual representation of the predefined data structure associated to the electronic record of the asset. The active tabs are respectively associated with predefined displays including the data fields provided by the predefined data structure, enabling a user to navigate through different displays corresponding to the data fields provided in the predefined data structure associated with the asset to view the metadata describing the asset.

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Michael Robinson