Xoft, Inc.

Edwards Lifesciences Corporation

Xoft Microtube, Inc.

Scimed Life Systems, Inc.

Edwards Lifesciences Ag

Teleflex Medical Devices S.a.r.l

Teleflex Life Sciences Pte. Ltd.

Michael Robert Forman

Darius Francescatti

Paul A Lovoi

David Mark Taylor

Ni Ding

Randall T Lashinski

Richard S Kusleika

Jonathan Swift Stinson

Eric Norman Rudie

Michael N Helmus

Donald E Bobo, Jr

Gerard Von Hoffmann

Peter Clark Smith

Tom W Rusch

Driver assemblies, drivers, drill bits, and methods for determining information (such as impedances, voltages, voltage differences, and changes in such information) about biological material during a medical procedure.

Driver assemblies, drivers, intraosseous devices, and methods for determining voltages and/or impedances in biological material

A breast brachytherapy applicator providing a stable semi permanent/permanent in dwelling platform that is configured to replicate anatomically the excised cancer bed and allows for a more precise anatomically correct delivery of limited field radiation treatment. This device may be used to reconstitute a resected tissue space to its pre-operative size and shape to 1) facilitate the accurate and precise delivery of adjunctive breast brachytherapy following breast cancer surgery and 2) prevent/decrease post-operative deformity as a result of surgical resection, whether for benign or malignant disease, and in particular after radiation treatment of malignant disease in the post lumpectomy patient.

Brachytherapy applicator

A flexible, relatively flat and thin patch, optionally made of biodegradable material, substantially attenuates ionizing radiation from normal but sensitive anatomy during radio-therapy, particularly breast brachytherapy. The patch is of such a thickness as to substantially attenuate radiation by distance or consists of a material that has been formulated with radio-attenuating filler or is of radio-attenuating material. An alternative version consists of a thin patch that is coated with radio-attenuating material.

Radiation blocking patch for radio-therapy

Disclosed are implants and methods for remote remodeling of a mitral valve annulus. The implant comprises a body transformable from a flexible configuration for navigation to a treatment site, to a remodeling configuration for, in one application, applying pressure to the posterior leaflet of the mitral valve. On board electronics allow post deployment adjustment of the implant.

Remotely activated mitral annuloplasty system and methods

A system and method to position and orient an excised breast tissue specimen on a support structure in a duplicate anatomic orientation relative to the operated breast is provided. One embodiment of the system includes an anatomically representative map of the breast under investigation. The system allows a surgeon to suture, ink, or otherwise fix the excised specimen on the map in accordance to its original position and orientation in the operated breast or organ. A radiogram of the excised specimen can be taken that shows the location of calcifications on a grid with radiopaque markers. The system allows a pathologist to cut through the specimen utilizing the map as a template in order to perform histological analysis and correlate the position and orientation of each slice to its anatomic position in the breast and thereby direct a precise and anatomically accurate re-excision by the surgeon if so required.

Gross pathology breast map

Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube inserted via a catheter around the globe of the eye, to a position behind the macula. The process can employ an applicator with several parallel guides, inserted around the eye to receive the catheter with x-ray tube (or an isotope) at a matrix of different positions. Methods are described for properly locating the catheter and x-ray tube, using illumination on the catheter and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent material excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube from the target tissue, and for achieving prescription radiation dose in the choroid while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.

Treatment of age-related macular degeneration

The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled immunomodulator delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and immunomodulator delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an immunomodulator to the body lumen.

Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia

The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled radiosensitizer delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and radiosensitizer delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, banier, coating, infusion lumen, stent, graft, or reservoir for releasing an radiosensitizer to the body lumen.

Combination ionizing radiation and radiosensitizer delivery devices and methods for inhibiting hyperplasia

A catheter and a method for using the catheter for site specific delivery of agents to or collecting agents from biological spaces. The catheter includes inflatable balloons which when inflated in a target segment of a biological space, create closed agent delivery pockets for the delivery or collection of agents from a defined space.

Multi-balloon drug delivery catheter for angiogenesis

A catheter and a method for using the catheter for site specific delivery of agents to or collecting agents from biological spaces. The catheter includes an inner shaft longitudinally movable within an outer shaft, each shaft having at least one balloon and at least one lumen formed therein. The catheter prevents leaking through a biological membrane by sealing the catheter tip passageway through the biological membrane with inflatable balloons on either side of the biological membrane. Further, the inflated balloons secure the position of the catheter relative to the biological membrane and the biological space targeted for therapy or diagnosis.

Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis

The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled drug delivery in combination with x-ray radiation delivery to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and agent delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an x-ray tube coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an agent to the body lumen.

Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia

A balloon catheter having a perfusion lumen communicating with a blood vessel, and a magnetically driven impeller disposed in the perfusion lumen to increase blood flow through the catheter and the arteries.

Perfusion balloon catheter

Apparatus and methods are provided for applying a radially uniform radiation dose to an intravascular treatment region to inhibit hyperplanes, and specifically to reduce &ldquo;candy-wrapper&rdquo; ends, following intravascular intervention. An embodiment of the apparatus comprises a catheter body having a proximal end and a distal end, a pair of axially spaced apart radiation shields on the catheter body, and a radiation source. The radiation source applies a radiation dose which is substantially uniform in a radial direction over an entire distance between the axially spaced apart shields.

Growing community of inventors

Los Gatos, CA, United States of America

Michael Robert Forman