Fresenius Ag

Michael Rinck

Bernd Mathieu

Wolfram Weber

Peter Konstantin

Jurgen Schnur

Dieter Selzer

A process for the immobilization of a linear polymer, in particular a polyionenes, which is soluble in an aqueous solvent, on a chemically inert carrier material and a matrix having an antimicrobial effect are provided, which are suitable for, in particularly intracorporeally applied, medical appliances and in the form of microporous membranes as filters for water purification or, in the form of beads, as a surface disinfectant. The process is characterized in that the two terminal reactive groups of the linear polymer are reacted with an excess of an alpha, omega-bifunctional compound, the reaction product obtained is dissolved in a hydrophilic solvent and applied at least once to the carrier material and then cross-linked with a cross-linking agent dissolved in a hydrophobic solvent which is chemically inert to the cross-linking agent and the carrier material.

Process for immobilizing linear polymers on a chemically inert carrier

The invention relates to a closure cap (1) for dialyzers which is suitable for a so-called in-line sterilization. For this purpose the closure cap (1) comprises two cap parts (2, 3) of which the first cap part (2) is adapted to be mounted on a dialyzer flange (4) while the second cap part (3) is arranged movably in a receiving compartment (5) of the first cap part (2) between an open position and a closure position. In an open position passage of a sterilization medium is possible so that all the parts, sealing and guide surfaces can be reliably sterilized. In the closure position the second cap part (3) is pushed into a sealing position within the first cap part (2) so that contamination of the dialyzer after removal from the sterilization apparatus can be prevented with certainty.

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St. Ingbert-Hassel, Germany

Michael Rinck