Bicycletx Limited

Michael Rigby

Gemma Elizabeth Mudd

Katerine Van Rietschoten

Peter U Park

Paul John Beswick

Liuhong Chen

Michael Skynner

Nicholas Keen

Ellen Gowans

Steven Stanway

Tara Gelb

Stephen Blakemore

Punit Seth

Liudvikas Urbonas

Peter Park

The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Bicyclic peptide ligands specific for Nectin-4

The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.

Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1)

Bicyclic peptide ligands specific for nectin-4

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Cambridge, United Kingdom

Michael Rigby