Merck Sharp + Dohme Corp.

Otsuka Pharmaceutical Company, Limited

Michael Reader

Philip Jones

David James Hallett

Kevin John Merchant

Simon Charles Goodacre

Alexander Charles Humphries

Jose Luis Castro Pineiro

Wesley Peter Blackaby

Kevin William Moore

Paul Anthony Baguley

Colin Thomas Lindley

Robert Craig Melling

Nicola Elizabeth Wilsher

Mirka Scarati

Mark Henry Saunders

Bozena Ewa Adamczyk

Sarah Margaret Kelly

This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

6-pyrimidin-isoindole derivative as ERK1/2 inhibitor

A class of 8-fluoro-3-phenylimidazo[1,2-&#x3b1;]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a &#x2014;NH&#x2014; or &#x2014;OCH&#x2014; linkage, being selective ligands for GABAreceptors, in particular having high affinity for the &#x3b1;2 and/or &#x3b1;3 and/or &#x3b1;5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

Imidazo-pyridine derivatives as ligands for GABA receptors

A class of 8-fluoroimidazo[1,2-&#x3b1;]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAreceptors, in particular having high affinity for the &#x3b1;2 and/or &#x3b1;3 and/or &#x3b1;5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

8-fluoroimidazo 1,2-a pyridine derivatives as ligands for GABA receptors

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Bishops Stortford, United Kingdom

Michael Reader