Nokia Corporation

Astrego Diagnostics Ab

Michael Read

Ove Öhman

Tapani Ryhänen

Martin Lovmar

Johan Elf

Özden Baltekin

Tomas Lindström

Olle Larsson

Mikael Olsson

Hans Otto Scheck

Elias Amselem

Petter Hammar

ÖZden Baltekin

Phenotyping of cells involves loading a biological sample into a microfluidic device () comprising cell compartments () to capture biological material, including target cells, in the sample in the cell compartments (). A subset (A) of the cell compartments () is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments () prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (A) of the cell compartments (). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.

Phenotypic characterization of cells

Manufacturing of miniaturised three-dimensional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro-replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.

Method for manufacturing a miniaturized three-dimensional electric component

Growing community of inventors

Uppsala, Sweden

Michael Read