E.i. Dupont De Nemours and Company

Bristol-myers Squibb Compnay

Michael Ramaker

Saverio Carl Falco

John N Feder

Jian Chen

Omolayo O Famodu

Mitchell Christian Tarczynski

Thomas C Nelson

Catherine J Thorpe

Dong Cheng

Jan Antoni Rafalski

Rupalie Meegalla

The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing MGAT3 polypeptides, fragments, and homologues thereof. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof

This invention relates to a nucleic acid fragment encoding a plant 5-methyltetra-hydropteroyltriglutamate-homocysteine methyltransferase or methionine synthase. The invention also includes chimeric genes, a first encoding a plant methionine synthase (MS) gene, a second encoding a plant cystathionine &#x3b3;-synthase (CS) gene, a third encoding feedback-insensitive aspartokinase (AK) or bifunctional feedback-insensitive aspartokinase-homoserine dehydrogenase (AK-HDH), which is operably linked to a plant chloroplast transit sequence, and a fourth encoding a methionine-rich protein, all operably linked to plant seed-specific regulatory sequences. Methods for their use to produce increased levels of methionine in the seeds of transformed plants are provided.

Plant methionine synthase gene and methods for increasing the methionine content of the seeds of plants

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Greenville, DE, United States of America

Michael Ramaker