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Basfaktiengesellschaft

Technische Universitaet Muenchen

Michael Rack

Joachim Gebhardt

Wolfgang Von Deyn

Michael Keil

Matthias Witschel

Bernd Wolf

Ernst Baumann

Joachim Rheinheimer

Siegfried Strathmann

Eberhard Ammermann

Gisela Lorenz

Wassilios Grammenos

Thomas Grote

Roland Goetz

Hubert Sauter

Ulf Misslitz

Volker Maywald

Thomas Zierke

Karl-Otto Westphalen

Helmut Walter

Reinhard Kirstgen

Klaus Oberdorf

Uwe Josef Vogelbacher

Volker Harries

Herbert Bayer

Deborah L Culbertson

Guido Mayer

Norbert G&ouml;tz

Martina Otten

Bernd Muller

Norbert Götz

Franz Rohl

Norbert Gotz

Helmut Hagen

Stefan Engel

Michael Puhl

Helmut Kraus

Hassan Oloumi-Sadeghi

Uwe Kardorff

Douglas D Anspaugh

Regina Luise Hill

Henricus Maria Martinus Bastiaans

Gerhard Hamprecht

Cyrill Zagar

Ruth Muller

Sebastian Soergel

Henry Van Tuyl Cotter

Markus Kordes

Roland G&ouml;tz

Jan Klaas Lohmann

Florian Kaiser

Thomas Schmidt

Albrecht Harreus

Karsten Koerber

Arne Ptock

Bernd W M&uuml;ller

Andreas Gypser

Liliana Parra Rapado

Joachim Dickhaut

Matthias Pohlman

Peter Sch&auml;fer

Olaf Menke

Markus Gewehr

Peter Plath

Bernd Mueller

Robert Reinhard

Frank Schieweck

Klaus Langemann

Thomas Seitz

Karl Eicken

Reinhard Stierl

Bernd Müller

Jordi Tormo I Blasco

Andreas Landes

Jochem Henkelmann

Trevor William Newton

Peter Schäfer

Bernd Sievernich

Oliver Wagner

Elisabeth Heistracher

Jochen Dietz

Hagen Jaedicke

Ingo Rose

Takeo Hokama

Ana Escribano Cuesta

Joaquim Henrique Teles

Gunther Lamm

Gary A Roth

Jens Lerchl

Horst Wingert

Christian Harald Winter

Harald Rang

Ralf Klintz

Klaus Kreuz

Klaus Grossmann

Johannes Hutzler

Werner Seitz

Horst Mayer

Ian Robert Craig

Anja Simon

The present invention relates to a novel crystalline form of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide recently assigned the common name dimpropyridaz. The invention also relates to the use of the crystalline form B for combating invertebrate pests and to formulations for plant protection which contain the crystalline form B of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide. The crystalline form B according to the present invention can be identified by powder X-ray diffractometry on the basis of its powder X-ray diffraction diagram, hereinafter also termed powder X-ray diffraction pattern or PXRD pattern, of the polymorph form B recorded using Cu—Kα radiation (1.54178 Å) at 25° C. displays the 3 following reflections, quoted as 2θ values: 20.69±0.10°, 24.15±0.10° and 30.52±0.10°. In addition to these 3 reflections, the polymorph B of the present invention may display in such a PXRD pattern one or more, in particular at least 2, often at least 4, in particular at least 6 or at least 8 reflections and especially all of the reflections quoted hereinafter as 2θ values: 7.99±0.10°, 10.07±0.10°, 12.38±0.10°, 15.31±0.10°, 15.97±0.10°, 16.50±0.10°, 18.03±0.10°, 19.29±0.10°, 20.22±0.0.10°, 20.96±0.10°, 23.40±0.10°, 23.70±0.10°, 26.09±0.10°, 27.26±0.10° and 32.91±0.10°.

Crystalline forms of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide

Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

Process for preparing 4-amino-pyridazines

Preparation of optionally substituted dihydroisoquinolines. The present invention relates to a process for the preparation of optionally substituted dihydroi-soquinolines of the formula I.

Preparation of optionally substituted dihydroisoquinolines

This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I), any one of its individual enantiomers or any non-racemic mixture thereof any one of its individual enantiomers or any non-racemic mixture thereof, comprising the steps of (a) reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II), any one of its individual enantiomers or any non-racemic mixture thereof (as defined in the description) with elemental sodium to form a sodium salt of the formula (III), any one of its individual enantiomers or any non-racemic mixture thereof (as defined in the description), and (b) reacting said sodium salt (III) with a 2-Methylbenzyl compound of the formula (IV) wherein X is a leaving group, wherein the steps (a) and (b) are conducted in the presence of at least one substantially anhydrous inert organic solvent.

Process for preparing 2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicy-clo[2.2.1]heptane

The present invention relates to a method for separating an optically active hydroxy cineole derivatives by lixiviation and crystallization and enantiomerically pure optically active hydroxy cineole derivatives of purity greater than 99.5% that have been prepared by this process. The present invention further relates to use of the desired enantiomer having enantiomeric excess of at least 99.5% ee as prepared according to the present invention, for the synthesis of enantiomerically pure 7-oxabicyclo[2.2.1]heptane derivatives.

Method for separating optically active hydroxy cineole derivatives

The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.

Process for preparing an optically active cineole derivative

The present invention relates to a process for the preparation pyridine derivatives of the formula (I). 

Bromination of pyridine derivatives

The present invention relates to a process for the preparation of pyridine derivatives of the formula (I) comprising two steps, namely, a selective chlorination followed by a selective fluorination. 

Halogenation of pyridine derivatives

The invention relates to a process for the preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene by diazotization and reduction of 6-bromo-2,4-dichloro-3-fluoro-aniline, which is obtained by bromination of 2,4-dichloro-3-fluoro-aniline, which is obtained by reduction of 1,3-dichloro-2-fluoro-4-nitro-benzene, and a process for preparing active compounds of formula V (Formula V) wherein the variables are defined in the specification by further transforming 5-bromo-1,3-dichloro-2-fluoro-benzene obtained from 2,4-dichloro-3-fluoro-aniline by the process according to the invention. 

Process for preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene

This invention relates to a process for preparing (&#xb1;)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-iso-propyl-7-oxabicyclo[2.2.1]heptane of the formula (I) any of its individual enantiomers or any non-racemic mixture thereof, comprising the step of reacting (&#xb1;)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II) any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (III) wherein X is a leaving group, in the presence of at least one base, at least one catalyst selected from rubidium salts, cesium salts and any combination thereof and at least one inert organic solvent S1.

Process for preparing 2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane

The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims or the description.

Process for preparing optically active 2,3-dihydrothiazolo[3,2-A]pyrimidin-4-ium compounds

This invention relates to a process for the epoxidation of a tetrasubstituted alkene such as terpinolene to the corresponding epoxide such as terpinolene epoxide by reacting the tetrasubstituted alkene with performic acid prepared in situ from formic acid and hydrogen peroxide in the presence of at least one buffering agent. Further, the invention relates to the use of an oxidizing agent comprising hydrogen peroxide and formic acid for the in-situ epoxidation of a tetrasubstituted alkene.

Process for the epoxidation of a tetrasubstituted alkene

Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are novel dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa. 

Preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles

The present invention relates to a process for the preparation of the compounds II from the respective oxo compounds. Furthermore, the invention relates to a process for the preparation of triazole compounds from oxiranes II.

Process for the preparation of substituted oxiranes and triazoles

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Eppelheim, Germany

Michael Rack