Colorado State University Research Foundation

Heska Corporation

Michael R McNeil

Nancy Wisnewski

Robert B Grieve

Donald L Wassom

The present invention relates to Trichinella diagnostic reagents that include a .beta.-tyvelose-containing composition and use of such reagents to detect Trichinella, and particularly Trichinella spiralis infections. The present invention also includes diagnostic kits based on such reagents and therapeutic agents based on the the knowledge that .beta.-tyvelose is produced by Trichinella spiralis parasites.

Carbohydrate-based vaccine and diagnostic reagent for trichinosis

The present invention relates to Trichinella diagnostic reagents that include at least one tyvelose-containing oligosaccharide, or functional equivalent thereof, and use of such reagents to detect Trichinella, and particularly Trichinella spiralis infections. The present invention also includes diagnostic kits based on such reagents and anti-Trichinella spiralis drugs based on the knowledge that tyvelose is produced by Trichinella spiralis parasites.

The present invention relates to Trichinella vaccines that include at least one tyvelose-containing oligosaccharide or functional equivalent thereof, to Trichinella vaccines that include at least one fucose-containing oligosaccharide or functional equivalent thereof, and to the use of such vaccines to protect animals from Trichinella infections, and particularly from trichinosis caused by Trichinella spiralis infection. Such vaccines can also be used to produce antibodies that are capable of protecting an animal from Trichinella infections and of diagnosing such infections. The present invention also relates to Trichinella diagnostic reagents that include at least one tyvelose-containing oligosaccharide, or functional equivalent thereof, and use of such reagents to detect Trichinella, and particularly Trichinella spiralis infections. The present invention also includes diagnostic kits based on such reagents and anti-Trichinella-spiralis drugs based on the knowledge that tyvelose is produced by Trichinella spiralis parasites.

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Ft. Collins, CO, United States of America

Michael R McNeil