Talres Development (n.a.) N.v.

Tate & Lyle Public Limited Company

Tate & Lyle, Inc.

Chemical Bank

Talres Development (n.a.)

Michael R Jenner

Riaz A Khan

Graham Jackson

Leslie Hough

David Waite

Shashikant P Phadnis

John C Williams

A sweetener concentrate containing sucralose and having improved thermal stability comprises particles of substantially non-crystalline sucralose dispersed evenly throughout, and adhering to, a water soluble oligosaccharide, the concentrate containing between about 20% and 80% sucralose on a dry weight basis. The oligosaccharide is preferably a glucose oligosaccharide such as maltodextrin. The concentrate can be prepared by forming a co-solution of the sucralose and oligosaccharide in water which is then dried. Other ingredients such as other high intensity sweeteners and flavorings may also be included.

Sucralose sweetening composition

Crystalline sucralose having a mean particle size of at most 10 microns, the maximum particle size being no more than twice the mean, exhibits enhanced stability to heat. Preferably the sucralose has a mean particle size of at most 5 microns and a maximum particle size of at most 10 microns. A method of enhancing the thermal stability of crystalline sucralose comprises jet milling the sucralose to reduce the particle size, and render the size distribution such that the maximum size is no more than twice the mean.

Sweetener

A method of sweetening a substance comprises incorporating therein a mono- or poly- chloro, mono- or poly- deoxy sucrose derivative having chlorine atoms in selected combinations of positions 4,6,1'- and 6'- of the sucrose molecule. The compounds are many times sweeter than sucrose and are formulated as ingestible products, such as foodstuffs and beverages; oral compositions, such as toothpaste and chewing gum; or sweetening compositions, such as tablets, for addition to beverages, etc.

Chloro-substituted sucrose compounds

Compounds of the general formula (I) are potent sweeteners, especially 4,1',6'-tribromo-4,1',6'-trideoxygalactosucrose: ##STR1## in which R' represents a chlorine or bromine atom;

Brominated sucrose derivatives, compositions and methods of use

Sweeteners

4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose is prepared by a process including the steps of:

Process for the preparation of

Crystalline 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose exists as the orthorhombic anhydrous form and as the pentahydrate, both of which are more stable than amorphous TGS. Crystals are obtained from seeded aqueous solutions, above 38.degree. C. for the anhydrate; below 38.degree. C. for the pentahydrate.

Crystalline 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose

A new chlorinated sucrose derivative, 2,6,1',6'-tetrachloro-2,6,1',6'-tetradeoxy-mannosucrose, is used as a bittering agent, e.g. to replace quinine sulphate, in ingestible compositions such as Indian tonic water, and in non-ingestible compositions.

Bittering agents

A process for the preparation of a 2-chloro-2-deoxy-mono-, di- or oligo-saccharide comprises reaction of a mono-, di- or oligo-saccharide derivative having a free hydroxy group in at least 2- position and having the hydroxy group in at least the 1- and 3- positions protected from chlorination, with sulphuryl chloride in the presence of an organic base in a chlorinated hydrocarbon solvent at a temperature below -40.degree. C. to form a chlorosulphate derivative with a chlorosulphate group in at least the 2-position, which chlorosulphate derivative is then reacted with lithium chloride in the presence of hexamethylphosphoric triamide to replace chlorosulphate groups with chlorine atoms to form a chlorodeoxy derivative, which chlorodeoxy derivative is then freed of unwanted protecting groups.

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Pangbourne, United Kingdom

Michael R Jenner