Apotex Inc.

Michael R Emmett

Fabio E S Souza

Prabhudas Bodhuri

Avedis Karadeolian

Gamini Weeratunga

Boris Gorin

Allan W Rey

Yajun Zhao

Stuart P Green

Alfredo Paul Ceccarelli

Eduardo Gustavo Cammisa

The present invention provides processes for the preparation of zuclomiphene, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the carbometallation of diphenylacetylene with a compound of Formula (3) to afford either zuclomiphene or an intermediate which is converted to zuclomiphene. 

Processes for the preparation of zuclomiphene and intermediates thereof

The present invention provides processes for the preparation of Tezacaftor, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the preparation of a compound of Formula (3), and its conversion to Tezacaftor (1). 

Processes for the preparation of Tezacaftor and intermediates thereof

The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1). 

Processes for the preparation of apalutamide and intermediates thereof

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Delaware, Canada

Michael R Emmett