Amgen Inc.

Michael R Comeau

Ian Nevin Foltz

Chadwick Terence King

Randal Robert Ketchem

Ai Ching Lim

Zhulun Wang

Dirk E Smith

Xiaoshan Min

Rutilio Clark

Donghui Shi

Christopher Mehlin

James F Smothers

Joel E Tocker

Bo-Rin P Yoon

Alison L Budelsky

David R Fitzpatrick

Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

ST2 antigen binding proteins

Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and derivatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

Antigen binding proteins capable of binding thymic stromal lymphopoietin

Methods of treating TSLP-related inflammatory disorders

Growing community of inventors

Bainbridge Island, WA, United States of America

Michael R Comeau