Quantitative Insights, Inc.

Arch Development Corporation

Michael R Chinander

Maryellen L Giger

Hui Li

Li Lan

Gillian M Newstead

Karen Drukker

Jeremy Bancroft Brown

Neha Bhooshan

Andrew Robert Jamieson

Robert Tomek

Chunsheng Jiang

Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyses. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique. Output to 3D shows relationships of the unknown case to a cloud of known or unlabeled cases, in which the cloud demonstrates the structure of the population of patients with and without the disease.

Method, system, software and medium for advanced intelligent image analysis and display of medical images and information

Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyzes. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique. Output to 3D shows relationships of the unknown case to a cloud of known or unlabeled cases, in which the cloud demonstrates the structure of the population of patients with and without the disease.

An automated method, storage medium, and system for analyzing bone. Digital image data corresponding to an image of the bone are obtained. Next there is determined, based on the digital images, a measure of bone mineral density (BMD) and at least one of a measure of bone geometry, a Minkowski dimension, and a trabecular orientation. The strength of the bone is estimated based upon the measure of BMD and at least one of the measure of bone geometry, the Minkowski dimension, and the trabecular orientation. To improve bone texture analysis, the present invention also provides a novel automated method, storage medium, and system in which digital image data corresponding to an image of the bone is obtained, and a region of interest (ROI) is selected within the bone. A fractal characteristic of the image data within the ROI using an artificial neural network is extracted. The strength of the bone is estimated based at least in part on the extracted fractal characteristic. To perform bone analysis with an improved measure of bone mineral density, the present invention also provides a novel automated method, storage medium, and system in which digital image data corresponding to an image of the bone is obtained. A measure of normalized bone mineral density (BMD) corresponding to a volumetric bone mineral density of the bone is determined, and the strength of the bone based is estimated based at least in part on the normalized BMD.

Method and system for the computerized analysis of bone mass and structure

Growing community of inventors

Chicago, IL, United States of America

Michael R Chinander