University of Utah Research Foundation

Prolexys Pharmaceuticals, Inc.

Michael Pierce

Duane E Ruffner

Paul B Robbins

Longwu Qi

Robert Selliah

Zhidong Chen

Raj Gopal Venkat

Sudhir R Sahasrabudhe

Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.

3-aryl-substituted quinazolones, and uses thereof

A method for making a directed antisense library against a target transcript is described. A cDNA of the target transcript is cloned in an appropriate cloning vector. Next, a plurality of deletion derivatives of the cloned cDNA is prepared such that the deletions serially extend into the cDNA from one end thereof. The resulting deletion library is then treated such that cDNA is removed from the other end of each cDNA insert, thus obtaining a fragment library having fragments of a selected size. A catalytic core is then inserted into each fragment of the fragment library, resulting in the directed antisense library. An illustrative antisense gene in the hammerhead ribozyme catalytic core. Plasmids for making the antisense library, plasmids and methods for making the fragment library, and a method for identifying target sites for antisense-mediated gene inhibition are also described.

Directed antisense libraries

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Salt Lake City, UT, United States of America

Michael Pierce