Deutsches Krebsforschungszentrum

Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Offentlichen Rechts

Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Oeffentlichen Rechts

Michael Pawlita

Markus Schmitt

Lutz Gissmann

Daniela Hoefler

Hanswalter Zentgraf

Manfred Frey

Iris Velhagen

Joris Braspenning

Wolfgang Meschede

Regina Martens

Masimo Tommasino

Tim Waterboer

Daniela HÖFLER

The present invention relates to a method for differentiating in a subject with HR-HPV between a severe form of HR-HPV infection and a mild form of HR-HPV infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with the method of the invention.

Diagnostic transcript and splice patterns of HR-HPV in different cervical lesions

A method is described for differentiating in a subject with HPV16 between (i) a severe form of HPV16 infection and (ii) a mild form of HPV16 infection based on determining the amount of a first gene product and a second gene product in a sample of a subject and calculating a ratio of the amount of the first gene product and the amount of the second gene product. A composition is also described, including an oligonucleotide mixture, and also a kit and a device adapted to carry out the described method.

Diagnostic transcript and splice patterns of HPV16 in different cervical lesions

The present invention relates to a method for determining contaminations in a cell culture sample comprising the steps of: a) contacting a sample of a cell culture suspected to comprise contaminations with a composition comprising oligonucleotides under conditions which allow for amplification of polynucleotides, wherein said oligonucleotides comprise oligonucleotides of at least three different groups of oligonucleotides, and b) determining the contaminations based on the amplified polynucleotides obtained by using the oligonucleotide groups of step (a). Moreover, the invention relates to a composition comprising an oligonucleotide mixture. Further encompassed by the present invention is a composition comprising a probe oligonucleotide mixture. Finally, the present invention also relates to kits comprising said oligonucleotide mixtures.

Composition comprising an oligonucleotide mixture for the detection of contaminations in cell cultures

The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject and a kit carrying out said method.

Composition comprising an oligonucleotide mixture for improved detection of human papillomavirus genotypes

Process for detecting specific antibodies acting against HPV proteins

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Eschelbronn, Germany

Michael Pawlita