Pfizer Corporation

Michael Paul Fitzgerald

Paul Vincent Fish

Trevor Jack Newbury

Richard Anthony Storey

Michael Butters

Julie Ann Macrae

Anthony David Auffret

Anne Bruckner

This invention relates to a process for controlling the hydrate mix of a compound, or a composition comprising the compound, the compound being capable of forming a plurality of hydration forms of differing stability and also of dissolution to give a solution that, when frozen below the eutectic point, is a eutectic mixture. This invention further relates to disodium salt of fosfluconazole in the form of its trihydrate, its hexahydrate, or as a mixture of tri- and hexahydrates.

Process for controlling the hydrate mix of a compound

The invention described herein relates to a process for the preparation of (7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine (I), intermediates thereto and new forms and formulations thereof, including the zwitterion monohydrate of (I), suitable for pharmaceutical use.

(7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine

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Sandwich, United Kingdom

Michael Paul Fitzgerald