Medical Research Council

University of Otago

Antipodean Pharmaceuticals, Inc.

Johnson and Johnson Vision Care, Inc.

Other

Vf Imagewear, Inc.

Michael Patrick Murphy

Robin Andrew James Smith

Robin A J Smith

Ben Rose

Ryan Hawke

Ross Franklin

Andy Milton

Jonathan Hansen

Richard Charles Hartley

Kourosh Saeb-Parsy

Kenneth Martin Taylor

Lorraine Work

Christian Frezza

Edward Chouchani

Thomas Krieg

Robin Smith

The invention relates to a succinate dehydrogenase inhibitor or a prodrug and/or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of reperfusion injury, such as ischemia-reperfusion injury, by inhibiting the accumulation of succinate, wherein the inhibitor or prodrug and/or pharmaceutically acceptable salt thereof is a cell-permeable reversible inhibitor of succinate dehydrogenase.

Succinate dehydrogenase inhibitors (SDHi's)

Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.

Compositions and methods for skin care

A new vision test, incorporating textual and non-textual elements in an image, is configured to demonstrate the effects of low cylinder astigmatism and other sources of blur on visual quality. The elements are designed to be noticeable, relevant, important and engaging. The new vision test may be utilized to supplement conventional vision testing.

Means and method for demonstrating the effects of low cylinder astigmatism correction

The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycemic diabetes. A mass spectrometry probe and to a method of labelling a biological molecule 1 for mass spectrometry detection are also described.

Mitochondria-targeted dicarbonyl sequestering compounds

A method for mapping wearer mobility includes identifying common usage patterns and usage positions by the garment wearer, attaching markers used in motion capture photography to the bare skin of a test subject, and recording position and movement data of the test subject with a computer system while the test subject repeats the common usage patterns and usage positions. The position and movement data are processed to create an opportunity map which identifies stretch and compression areas of the test subject. Markers are attached to a garment worn by a test subject, and position and movement data are recorded while the test subject repeats the common usage patterns and usage positions. The data are analyzed to create a problem map which identifies stretch and compression areas of the garment. A mobility map is created based on the opportunity map and problem map that creates a garment design that reduces compression and stretch areas.

System and method for mapping wearer mobility for clothing design

The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.

Nitric oxide donors

This invention relates to methods to screen for, identify, select and synthesise amphiphilic mitochondrially targeted antioxidant compounds, and compositions, dosage forms and methods reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.

Mitoquinone derivatives used as mitochondrially targeted antioxidants

The methods of preparing quinols and quinones typified by mitoquinol and mitoquinone where a compound typified by idebenone is reacted with PhPHX and PhP, where X is a halogen atom.

Synthesis of triphenylphosphonium quinols and quinones

The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.

Mitochondrially targeted antioxidants

The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.

Growing community of inventors

Cambridge, United Kingdom

Michael Patrick Murphy