Merck Sharp + Dohme Corp.

Sumitomo Bakelite Company Limited

Somalogic, Incorporated

Michael Patrick Coleman

Mark C Sleevi

Allison D Ortigosa

Kartoa Chow

Dominic Zichi

Takayuki Matsumoto

Kanehisa Yokoyama

Sumio Shibahara

Daisuke Masuda

Mitsutaka Matsumoto

Michael A Rauscher

Sohei Funaoka

Shibu T George

Takayuki Sumitomo Bakelite Company Ltd Matsumoto

Sohei Sumitomo Bakelite Company Ltd Funaoka

Kanehisa Sumitomo Bakelite Company Ltd Yokoyama

Mitsutaka Sumitomo Bakelike Comp Ltd Matsumoto

Daisuke Sumitomo Bakelite Company Ltd Masuda

Sumio Sumitomo Bakelite Company Ltd Shibahara

A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed in the presence of a water miscible organic modifier and at an elevated temperature followed by reverse phase chromatography performed in the presence of a water miscible organic modifier and at an elevated temperature.

Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature

A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed under low to moderate pressure at an elevated temperature.

Process for purifying insulin and analogues thereof

A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

Polymer compound for biomedical use and biochip substrate using such a polymer compound

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Louisville, CO, United States of America

Michael Patrick Coleman