Stauffer Chemical Company

Ici Americas, Inc.

Imperial Chemical Industries Limited

Zeneca Limited

Exelixis, Inc.

Michael P Prisbylla

Moon Jung Kim

Wei Xu

John M Nuss

Vasu Jammalamadaka

Shumeye Mamo

Morrison B Mac

S David Brown

Erick Wang Co

Amy Lew Tsuhako

Donna Tra Le

Lynne Canne-Bannen

Rickard George Khoury

David B Kanne

Siok H Wee

Sven T Lindstedt

Edward A Lock

Maj E Markstedt

Linda C Mutter

Martin K Ellis

The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.

Human adam-10 inhibitors

Human ADAM-10 inhibitors

Herbicidal 5-substituted pyrimidine compounds and derivatives thereof of the formula: ##STR1## Herbicidal compositions containing such 5-substituted pyrimidine compounds and derivatives thereof and methods of controlling undesirable vegetation using these compounds and derivatives are also disclosed. The compounds in which XR is hydroxyl are also useful as intermediates for producing the 5-substituted pyrimidine derivatives of the invention.

Herbicidal 5-substituted pyrimidine compounds and derivatives thereof

The invention concerns novel pharmaceutical compositions containing as an active ingredient a 2-benzoyl-1,3-cyclohexanedione which is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD). The compositions are valuable in the treating those disorders and diseases in which it is desirable to intervene in the metabolic sequences catalysed by HPPD, such as in treating tyrosinemia type I.

Pharmaceutical compositions for the treatment of hereditary tyosinemia

Compounds having the formula ##STR1## in which: R is hydrogen, 2-halo, 2-(C.sub.1 -C.sub.4 alkyl), 2-trifluoromethyl, 2-(C.sub.1 -C.sub.4 alkoxy), 4-fluoro or, 2,6-dihalo;

Pyridone herbicides

Compounds having the formula ##STR1## in which: R is hydrogen, 2-halo, 2-(C.sub.1 -C.sub.4 alkyl), 2-trifluoromethyl, 2-nitro, 2-(C.sub.1 -C.sub.4 alkoxy), 4-halo, 2-halo-6-butynyloxy, or 2,6-dihalo;

Fused pyridine herbicides

2,4-Diarylpyrimidines of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## R.sub.1 and R.sub.2 are independently selected from the group consisting of H, Br, Cl, F, C.tbd.N, CF.sub.3 and OCF.sub.3 ;

Substituted 2,4-diarylpyrimidines and their use as herbicides

This invention relates to 5-substituted-3-phenyl-imidazolidine-2,4-diones, to a process for their preparation and to their use in herbicidal formulations. In particular, this invention relates to 5-substituted-3-phenyl-imidazolidine-2, 4-diones of the formula I ##STR1## in which: p0 X is hydrogen or halogen; p0 R is selected from the group --R.sup.2 or .dbd.CH--R.sup.3 ; p0 R.sup.1 is methyl or ethyl; p0 R.sup.2 is C.sub.1-8 alkyl, C.sub.1-8 haloalkyl, C.sub.3-8 cycloalkyl, C.sub.4-10 cycloalkylalkyl, phenyl, benzyl or substituted benzyl; and

Process for the preparation of 5-substituted-3-phenyl

This invention relates to 5-substituted-3-phenyl-imidazolidine-2,4-diones, to a process for their preparation and to their use in herbicidal formulations.

Herbicidal 5-substituted-3-phenyl-imidazolidine-2,4-diones

5-Substituted 2,4-imidazolidinediones having the formula ##STR1## wherein R is alkyl, phenyl or phenyl substituterd with alkyl, alkoxy, halo, haloalkyl, nitro or combinations thereof;

Herbicidal 5-substituted-2-4-imidazolidinediones

Compounds of the formula ##STR1## wherein R is alkyl, phenyl, substituted phenyl, alkylsulfonyl, alkoxy, halo or haloalkyl; R.sub.1 is hydrogen, alkyl, phenyl, or halo substituted phenyl; R.sub.2 is hydrogen or alkyl; R.sub.3 is ##STR2## wherein R.sub.4 and R.sub.5 are independently hydrogen, alkyl, phenyl, halophenyl, phenalkyl, halophenalkyl, cycloalkyl, cycloalkylmethyl, naphthyl, pyridyl, pyridylalkyl, or R.sub.4 and R.sub.5 taken together with nitrogen form a hexamethyleneimine, piperidine, phenylpiperidine, benzylpiperidine, indoline, phenyl indoline or perhydroindole; and V is oxygen or sulfur; provided that when R.sub.1 is methyl and R.sub.3 is ##STR3## wherein R.sub.4 is methyl and R.sub.5 is phenyl, then R is other than 2-chlorophenyl or 2-methoxyphenyl; and when R.sub.1 is hydrogen or ethyl and R.sub.3 is ##STR4## wherein R.sub.4 is methyl and R.sub.5 is phenyl, then R is other than 3,4-dichlorophenyl; and herbicidal compositions and methods utilizing said compounds.

Novel 5-aminomethylene-2,4-imidazolidinediones and

As compounds, diphenyl ether derivatives of the formula ##STR1## wherein X, Y and Z are the same or different and are selected from the group consisting of trifluoromethyl, halogen and hydrogen, and wherein R is selected from those having the formula ##STR2## in which R' and R' are selected from the group consisting of lower alkyl groups having from 1 to 3 carbon atoms, and agriculturally acceptable salts thereof.

Diphenyl ether herbicides

The aluminum salt of N-phosphonomethylglycine as a unique compound which has utility as a post-emergence herbicide and is also useful as a plant growth regulator; and herbicidal and growth regulating compositions comprising the compound aluminum N-phosphonomethylglycine.

Aluminum N-phosphonomethylglycine and its use as a herbicide

A herbicidal composition comprising stannic N-phosphonomethylglycine having a ratio of stannic (IV) cation to N-phosphonomethylglycine anion is from about 1:1 to about 1:6, and their use as herbicides.

Stannic N-phosphonomethyglycine and its use as a herbicide

As a new compound, mixed alkylsulfonium salts of N-phosphonomethylglycine having the formula ##STR1## wherein R.sup.1 is selected from the group consisting of long-chain saturated or unsaturated alkyl groups having from 12 to 20 carbon atoms and R.sup.2 and R.sub.3 are the same or different and are selected from the group consisting of lower alkyl having from 1-3 carbon atoms.

Growing community of inventors

Richmond, CA, United States of America

Michael P Prisbylla