The Scripps Research Institute

Michael P Ledbetter

Floyd E Romesberg

Rebekah J Karadeema

Aaron W Feldman

Vivian T Dien

Anne Xiaozhou Zhou

Lingjun Li

Disclosed herein are methods, cells, engineered microorganisms, and kits for increasing the production of polypeptides comprising one or more unnatural amino acids. Further provided are cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

Unnatural base pair compositions and methods of use

Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

Reagents and methods for replication, transcription, and translation in semi-synthetic organisms

Growing community of inventors

La Jolla, CA, United States of America

Michael P Ledbetter