Schering Corporation

Michael P Kirkup

Neng-Yang Shih

Ashit K Ganguly

John J Piwinski

Robert G Aslanian

Stuart W McCombie

Kevin D McCormick

Pauline C Ting

Bandarpalle B Shankar

Pietro Mangiaracina

Gregory A Reichard

Nareshkumar F Jain

Nicholas I Carruthers

Michael A Marella

James M Spitler

Cheryl A Alaimo

Andrew Lupo, Jr

Amy Sommese Boland

Sanjeevani A Ghone

Sundeep Dugar

Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3;

Substituted oximes, hydrazones and olefins as neurokinin antagonists

Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or 3;

Substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is R.sup.3 -substituted aryl;

Substituted azetidinone compounds useful as hypocholesterolemic agents

Azetidinones represented by the formula ##STR1## are prepared by a multistep process from L-(-)-theonine via an epoxyamide.

Stereospecific preparation of

Novel and useful silylenol intermediates for preparing penem and carbapenem antibacterials and a process for making selected intermediates are disclosed.

Intermediate compounds for preparing penems and carbapenems

There is disclosed antibacterial compounds represented by the formula ##STR1## and pharmaceutically acceptable salts or pharmaceutically acceptable esters thereof, wherein:

6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates

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Lawrenceville, NJ, United States of America

Michael P Kirkup