Bayer Healthcare LLC

Michael P Houlne

Mihailo V Rebec

James E Smous

A non-invasive method of determining the concentration of an analyte uses Raman spectral information. A high-intensity, narrow band of light () is applied to one side () of skin tissue (). The high-intensity light () enters the skin tissue and generates a Raman signal (). A reflective material () is placed in a location nearest the other side () of skin tissue (). The reflective material () is located generally opposite of the entry (A) of the applied high-intensity light (). The high-intensity light () and the Raman signal () that pass through the skin tissue () are reflected back into the skin tissue () via the reflective material (). The Raman signal () is collected and the analyte concentration is determined using the collected Raman signal ().

Methods of using Raman spectral information in determining analyte concentrations

A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence-generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.

Non-invasive methods of using spectral information in determining analyte concentrations

A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.

Growing community of inventors

Centennial, CO, United States of America

Michael P Houlne