Sanford Burnham Prebys Medical Discovery Institute

Sanford-burnham Medical Research Institute

University of Michigan

Wayne State University

University of Kansas-ku Medical Center Research Institute

La Jolla Institute of Allergy & Immunology

Duke University

Michael P Hedrick

Anthony B Pinkerton

Paul M Hershberger

Patrick R Maloney

Satyamaheshwar Peddibhotla

Thomas D Y Chung

Robert J Ardecky

Jeffrey Aube

Jennifer Elizabeth Golden

Daniel Patrick Flaherty

Randal J Kaufman

Jiwen Zou

Nunzio Bottini

Stephanie M Stanford

Santhi Reddy Ganji

Andrew M Fribley

Marc G Caron

Lawrence S Barak

Lawrence Barak

Santhi R Ganji

Thomas Chung

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Small molecule agonists of neurotensin receptor 1

Herein are provided, inter, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A). 

Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof

N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

Compounds and methods for activating the apoptotic arm of the unfolded protein response

Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A). 

N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

Growing community of inventors

La Jolla, CA, United States of America

Michael P Hedrick