Princeton University

Other

Michael P Danahy

Jeffrey J Schwartz

Michael J Avaltroni

Jean E Schwarzbauer

Kim S Midwood

Michael D Carolus

Brett M Silverman

Eric L Hanson

Ellen S Gawalt

Jing Guo

Process for forming a coated article by (a) depositing a layer of an omega functionalized organophosphorous compound on an oxide substrate; (b) heating the substrate of step (a) to a temperature sufficient to bond the omega functionalized organophosphorous compound to the oxide substrate; (c) depositing a separate layer onto the layer produced by step (b); and (d) bonding the layers produced by steps (b) and (c) through the omega functional group.

Enhanced bonding layers on native oxide surfaces

Methods for bonding adherent phosphorous-containing coating layers to oxide surfaces on substrates wherein the substrates with oxide surfaces are selected from:

Carrier applied coating layers

The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.

Enhanced bonding layers on titanium materials

An implantable device with a metal, metal alloy, metalloid, polymeric or ceramic surface and a phosphonic acid coating layer directly contacting the surface wherein the surface has hydroxyl groups covalently bonded to the acid groups of the coating layer and the phosphonate organic ligands are omega-functionalized.

The present invention provides a process for providing on the surface of a substrate an adherent phorphorous acid-based coating layer, the method comprising contacting said surface with a carrier conveying a coating composition comprising an acid selected from the group consisting of phosphoroic acids, organo-phosphoric acids, phosphonic acids, and mixtures thereof, at a sufficient temperature and for a sufficient time to bond at least a portion of the acid in the compositon to the oxide surface.

Growing community of inventors

Princeton, NJ, United States of America

Michael P Danahy