Quest Diagnostics Investments, Inc.

Los Angeles Biomedical Research Institute

Michael P Caulfield

Nigel J Clarke

Richard E Reitz

Darren J Weber

Scott Goldman

Gloria Kwangja Lee

W Henry Benner

Ronald M Krauss

Earl Cornell

Patricia J Blanche

Shuguang Li

Darren A Carns

Wael A Salameh

Kamyar Kalantar-Zadeh

Jackie Liu

Dawn Shalhout

Zhihong Chen

Kamyar Kalantar-Zedeh

Michael J McPhaul

The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.

Lipoprotein analysis by differential charged-particle mobility

Described herein are methods for determining the overall survival of maintenance hemodialysis patients. The methods include measuring low density lipoprotein (LDL) particle size and subfraction concentrations as prognostic tools for early mortality risk detection. For example, the presence of increased very small LDL concentration or decreased LDL particle size in blood-serum serves as a useful means for prognostic risk assessment and monitoring.

Prognostic assays for maintenance hemodialysis patients

The present invention provides devices and methods for identification and/or quantitation of particles through detection of fluorescence labeled particles in an apparatus for differential charged particle mobility analysis and fluorescence detection.

Detection apparatus for differential-charged particle mobility analyzer

The invention provides apparatus and methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged-particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged-particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.

Magnetic separation of lipoproteins using dextran sulfate

Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample.

Methods for detecting catecholamines by mass spectrometry

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San Clemente, CA, United States of America

Michael P Caulfield