Sandoz Ag

Michael Oberhuber

Dominic De Souza

Martin Albert

Joerg Salchenegger

Hubert Sturm

Thorsten Wilhelm

Martin Langner

Hans-Peter Spitzenstaetter

Jörg Salchenegger

Hans-Peter SPITZENSTÄTTER

The present invention relates to a process for the preparation of a chiral compound according to formula (V) wherein Ris preferably an alkyl residue preferably having from 1 to 6 carbon atoms, in particular to a process for the preparation of a chiral compound the crystalline chiral compounds as such, and their use for the preparation of an antifungal agent, in particular posaconazole. 

Process for the preparation of chiral hydrazides

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y&#x2014;NH; of formula (IIa) 0=C&#x2550;N&#x2014;Yand/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V). 

Process for the preparation of chiral triazolones

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Bozen, Italy

Michael Oberhuber