Merlin Md Pte Ltd.

Michael O'Connor

Leon Rudakov

Deepak R Gandhi

Tsui Ying Rachel Hong

Vimal Raj D

A method for treating an aneurysm can include inserting a medical device partially in a first artery and partially in a third artery. The device can be expanded radially outwardly from a first, position to a second position to engage an inner surface of the first artery and an inner surface of the third artery, so as to maintain a fluid pathway through said arteries. Further, the device can be positioned such that, when the device is in the second position, a porous membrane of the device is located at a neck of the aneurysm.

Medical device

A method for treating an aneurysm can include inserting a medical device partially in a first artery and partially in a third artery. The device can be expanded radially outwardly from a first position to a second position to engage an inner surface of the first artery and an inner surface of the third artery, so as to maintain a fluid pathway through said arteries. Further, the device can be positioned such that, when the device is in the second position, a porous membrane of the device is located at a neck of the aneurysm.

A medical device for insertion into a bodily vessel to treat an aneurysm (), the device comprising: a mechanically expandable device () expandable from a first position to a second position, said mechanically expandable device () is expanded radially outwardly to the second position such that the exterior surface of said mechanically expandable () engages with the inner surface of the vessel so as to maintain a fluid pathway through said vessel; and a membrane () expandable from a first position to a second position in response to expansion of said mechanically expandable device (), said membrane () obstructing blood circulation to the aneurysm () when expanded to the second position, and at least a portion of the membrane () is secured to the mechanically expandable device () to maintain the position of the membrane () relative to the mechanically expandable device () when expanded to the second position.

Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 &#x3bc;m. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 &#x3bc;m. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.

Endovascular device with membrane

A method for treating a bifurcation or trifurcation aneurysm () occurring on a first artery, the first artery and a second artery joining to a third artery, the method comprising: inserting a medical device () such that it is at least partially located in the first artery and is at least partially located in the third artery; expanding the medical device () from a first position to a second position, said medical device () is expanded radially outwardly to the second position such that the exterior surface of said medical device () engages with the inner surface of the first and third arteries so as to maintain a fluid pathway through said arteries; and positioning the medical device () such that a membrane () of the medical device () is located against an aneurysm neck of the aneurysm () to obstruct blood circulation to the aneurysm () when the medical device () is expanded to the second position, and at least a portion of the membrane () is secured to the medical device () to maintain the position of the membrane () relative to the medical device () when expanded to the second position; wherein the membrane () is permeable and porous, the size of the pores of the membrane () and the ratio of the material surface area of the membrane () being such that blood supply to perforators and/or microscopic branches of main brain arteries is permitted to improve healing of the first artery but blood supply to the aneurysm () is prevented.

An implantable mechanical device for insertion into a passage, where the device is made from a platinum alloy selected from the group consisting of platinum:iridium alloy, platinum:tungsten alloy, platinum:rhodium:ruthenium alloy, platinum:rhodium alloy and platinum:nickel alloy.

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Singapore, Singapore

Michael O'Connor